7B5R

Ubiquitin ligation to F-box protein substrates by SCF-RBR E3-E3 super-assembly: CUL1-RBX1-SKP1-SKP2-CKSHS1-Cyclin A-CDK2-p27

Summary for 7B5R

• Entry DOI: 10.2210/pdb7b5r/pdb
• Related: 7B5L
• EMDB information: 12004 12005 12006 12007 12036 12037 12038 12048
• Descriptor: Cullin-1, S-phase kinase-associated protein 2, Cyclin-dependent kinases regulatory subunit 1, ... (7 entities in total)
• Functional Keywords: ubiquitin, ubiquitin ligase, e3 ligase, f-box protein, rbr ligase, cullin-ring-ligase, crl, scf, nedd8, post-translational modification, ubiquitylation, ligase
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 7
• Total formula weight: 270831.67

Authors

Horn-Ghetko, D.,Prabu, J.R.,Schulman, B.A. (deposition date: 2020-12-07, release date: 2021-02-10, Last modification date: 2021-03-10)

• Primary citation: Horn-Ghetko, D.,Krist, D.T.,Prabu, J.R.,Baek, K.,Mulder, M.P.C.,Klugel, M.,Scott, D.C.,Ovaa, H.,Kleiger, G.,Schulman, B.A.; Ubiquitin ligation to F-box protein targets by SCF-RBR E3-E3 super-assembly.; Nature, 590:671-676, 2021; PubMed: 33536622; DOI: 10.1038/s41586-021-03197-9

Experimental method

ELECTRON MICROSCOPY (3.8 Å)