7B5R
Ubiquitin ligation to F-box protein substrates by SCF-RBR E3-E3 super-assembly: CUL1-RBX1-SKP1-SKP2-CKSHS1-Cyclin A-CDK2-p27
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | C | Cullin-1 | polymer | 776 | 89800.4 | 1 | UniProt (Q13616) Pfam (PF00888) Pfam (PF10557) In PDB | Homo sapiens (Human) | CUL-1 |
| 2 | T | S-phase kinase-associated protein 2 | polymer | 424 | 47817.8 | 1 | UniProt (Q13309) Pfam (PF12937) In PDB | Homo sapiens (Human) | Cyclin-A/CDK2-associated protein p45,F-box protein Skp2,F-box/LRR-repeat protein 1,p45skp2 |
| 3 | K | Cyclin-dependent kinases regulatory subunit 1 | polymer | 79 | 9679.2 | 1 | UniProt (P61024) Pfam (PF01111) In PDB | Homo sapiens (Human) | CKS-1 |
| 4 | S | S-phase kinase-associated protein 1 | polymer | 163 | 18680.0 | 1 | UniProt (P63208) Pfam (PF03931) Pfam (PF01466) In PDB | Homo sapiens (Human) | Cyclin-A/CDK2-associated protein p19,p19A,Organ of Corti protein 2,OCP-2,Organ of Corti protein II,OCP-II,RNA polymerase II elongation factor-like protein,SIII,Transcription elongation factor B polypeptide 1-like,p19skp1 |
| 5 | L | Cyclin-dependent kinase 2 | polymer | 298 | 34056.5 | 1 | UniProt (P24941) Pfam (PF00069) In PDB | Homo sapiens (Human) | Cell division protein kinase 2,p33 protein kinase |
| 6 | Y | Cyclin-A2 | polymer | 432 | 48609.6 | 1 | UniProt (P20248) Pfam (PF00134) Pfam (PF02984) Pfam (PF16500) In PDB | Homo sapiens (Human) | Cyclin-A,Cyclin A |
| 7 | P | Cyclin-dependent kinase inhibitor 1B | polymer | 198 | 22188.3 | 1 | UniProt (P46527) Pfam (PF02234) In PDB | Homo sapiens (Human) | Cyclin-dependent kinase inhibitor p27,p27Kip1 |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 7 |
| Total formula weight | 270831.7 | |
| All* | Total formula weight | 270831.7 |
