7NJ0

CryoEM structure of the human Separase-Cdk1-cyclin B1-Cks1 complex

Summary for 7NJ0

Entry DOI	10.2210/pdb7nj0/pdb
EMDB information	12368
Descriptor	Securin,Separin, Cyclin-dependent kinase 1, G2/mitotic-specific cyclin-B1,G2/mitotic-specific cyclin-B1, ... (5 entities in total)
Functional Keywords	autoinhibition phosphate-binding pocket pseudosubstrate scc1, hydrolase
Biological source	Homo sapiens (Human) More
Total number of polymer chains	4
Total formula weight	343744.33
Authors	Yu, J.,Raia, P.,Ghent, C.M.,Raisch, T.,Sadian, Y.,Barford, D.,Raunser, S.,Morgan, D.O.,Boland, A. (deposition date: 2021-02-14, release date: 2021-08-04, Last modification date: 2021-08-18)
Primary citation	Yu, J.,Raia, P.,Ghent, C.M.,Raisch, T.,Sadian, Y.,Cavadini, S.,Sabale, P.M.,Barford, D.,Raunser, S.,Morgan, D.O.,Boland, A. Structural basis of human separase regulation by securin and CDK1-cyclin B1. Nature, 596:138-142, 2021 Cited by PubMed: 34290405 DOI: 10.1038/s41586-021-03764-0 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.6 Å)

Structure validation