7NJ0
CryoEM structure of the human Separase-Cdk1-cyclin B1-Cks1 complex
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Securin,Separin | polymer | 2233 | 244677.3 | 1 | UniProt (O95997) UniProt (Q14674) Pfam (PF03568) In PDB | Homo sapiens (Human) | Esp1-associated protein,Pituitary tumor-transforming gene 1 protein,Tumor-transforming protein 1,hPTTG,Caspase-like protein ESPL1,Extra spindle poles-like 1 protein,Separase |
2 | B | Cyclin-dependent kinase 1 | polymer | 318 | 36667.1 | 1 | UniProt (P06493) Pfam (PF00069) In PDB | Homo sapiens (Human) | CDK1,Cell division control protein 2 homolog,Cell division protein kinase 1,p34 protein kinase |
3 | C | G2/mitotic-specific cyclin-B1,G2/mitotic-specific cyclin-B1 | polymer | 473 | 52625.7 | 1 | UniProt (P14635) Pfam (PF00134) Pfam (PF02984) In PDB | Homo sapiens (Human) | |
4 | D | Cyclin-dependent kinases regulatory subunit 1 | polymer | 79 | 9679.2 | 1 | UniProt (P61024) Pfam (PF01111) In PDB | Homo sapiens (Human) | CKS-1 |
5 | D | PHOSPHATE ION | non-polymer | 95.0 | 1 | Chemie (PO4) |
Sequence modifications
A: -71 - -29 (UniProt: O95997)
A: 1 - 2120 (UniProt: Q14674)
B: 1 - 297 (UniProt: P06493)
C: 1 - 433 (UniProt: P14635)
C: 434 - 473 (PDB: 7NJ0)
PDB | External Database | Details |
---|---|---|
Met -72 | - | initiating methionine |
Gly -28 | - | linker |
Gly -27 | - | linker |
Ser -26 | - | linker |
Gly -25 | - | linker |
Gly -24 | - | linker |
Ser -23 | - | linker |
Gly -22 | - | linker |
Gly -21 | - | linker |
Gly -20 | - | linker |
Ser -19 | - | linker |
Gly -18 | - | linker |
Gly -17 | - | linker |
Gly -16 | - | linker |
Ser -15 | - | linker |
Gly -14 | - | linker |
Glu -13 | - | linker |
Asn -12 | - | linker |
Leu -11 | - | linker |
Tyr -10 | - | linker |
Phe -9 | - | linker |
Gln -8 | - | linker |
Gly -7 | - | linker |
Gly -6 | - | linker |
Gly -5 | - | linker |
Ser -4 | - | linker |
Gly -3 | - | linker |
Gly -2 | - | linker |
Ser -1 | - | linker |
Gly 0 | - | linker |
PDB | External Database | Details |
---|---|---|
Asp 25 | Ala 25 | conflict |
Val 116 | Ala 116 | conflict |
Ile 693 | Met 693 | conflict |
Ser 1329 | Arg 1329 | conflict |
Gln 1561 | Arg 1561 | conflict |
Ser 2029 | Cys 2029 | conflict |
His 2037 | Arg 2037 | conflict |
Ser 2121 | - | expression tag |
Ser 2122 | - | expression tag |
Leu 2123 | - | expression tag |
Ala 2124 | - | expression tag |
Glu 2125 | - | expression tag |
Glu 2126 | - | expression tag |
Asn 2127 | - | expression tag |
Leu 2128 | - | expression tag |
Tyr 2129 | - | expression tag |
Phe 2130 | - | expression tag |
Gln 2131 | - | expression tag |
Ser 2132 | - | expression tag |
Trp 2133 | - | expression tag |
Ser 2134 | - | expression tag |
His 2135 | - | expression tag |
Pro 2136 | - | expression tag |
Gln 2137 | - | expression tag |
Phe 2138 | - | expression tag |
Glu 2139 | - | expression tag |
Lys 2140 | - | expression tag |
Gly 2141 | - | expression tag |
Gly 2142 | - | expression tag |
Gly 2143 | - | expression tag |
Ser 2144 | - | expression tag |
Gly 2145 | - | expression tag |
Gly 2146 | - | expression tag |
Gly 2147 | - | expression tag |
Ser 2148 | - | expression tag |
Gly 2149 | - | expression tag |
Gly 2150 | - | expression tag |
Gly 2151 | - | expression tag |
Ser 2152 | - | expression tag |
Trp 2153 | - | expression tag |
Ser 2154 | - | expression tag |
His 2155 | - | expression tag |
Pro 2156 | - | expression tag |
Gln 2157 | - | expression tag |
Phe 2158 | - | expression tag |
Glu 2159 | - | expression tag |
Lys 2160 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Ile 298 | - | expression tag |
Ala 299 | - | expression tag |
Ala 300 | - | expression tag |
Glu 301 | - | expression tag |
Ala 302 | - | expression tag |
Leu 303 | - | expression tag |
Glu 304 | - | expression tag |
Val 305 | - | expression tag |
Leu 306 | - | expression tag |
Phe 307 | - | expression tag |
Gln 308 | - | expression tag |
Gly 309 | - | expression tag |
Pro 310 | - | expression tag |
His 311 | - | expression tag |
His 312 | - | expression tag |
His 313 | - | expression tag |
His 314 | - | expression tag |
His 315 | - | expression tag |
His 316 | - | expression tag |
His 317 | - | expression tag |
His 318 | - | expression tag |
C: 434 - 473 (PDB: 7NJ0)
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 343649.4 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 95.0 | |
All* | Total formula weight | 343744.3 |