6GU6

CDK1/Cks2 in complex with Dinaciclib

Summary for 6GU6

Entry DOI	10.2210/pdb6gu6/pdb
Descriptor	Cyclin-dependent kinase 1, Cyclin-dependent kinases regulatory subunit 2, 3-[({3-ethyl-5-[(2S)-2-(2-hydroxyethyl)piperidin-1-yl]pyrazolo[1,5-a]pyrimidin-7-yl}amino)methyl]-1-hydroxypyridinium, ... (4 entities in total)
Functional Keywords	cdk1, cks2, inhibitor, cell cycle
Biological source	Homo sapiens (Human) More
Total number of polymer chains	2
Total formula weight	45242.20
Authors	Wood, D.J.,Korolchuk, S.,Tatum, N.J.,Wang, L.Z.,Endicott, J.A.,Noble, M.E.M.,Martin, M.P. (deposition date: 2018-06-19, release date: 2018-12-05, Last modification date: 2024-01-17)
Primary citation	Wood, D.J.,Korolchuk, S.,Tatum, N.J.,Wang, L.Z.,Endicott, J.A.,Noble, M.E.M.,Martin, M.P. Differences in the Conformational Energy Landscape of CDK1 and CDK2 Suggest a Mechanism for Achieving Selective CDK Inhibition. Cell Chem Biol, 26:121-130.e5, 2019 Cited by PubMed: 30472117 DOI: 10.1016/j.chembiol.2018.10.015 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.33 Å)

Structure validation