6GU6
CDK1/Cks2 in complex with Dinaciclib
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Cyclin-dependent kinase 1 | polymer | 302 | 34553.9 | 1 | UniProt (P06493) Pfam (PF00069) | Homo sapiens (Human) | CDK1,Cell division control protein 2 homolog,Cell division protein kinase 1,p34 protein kinase |
| 2 | B (B) | Cyclin-dependent kinases regulatory subunit 2 | polymer | 84 | 10290.8 | 1 | UniProt (P33552) Pfam (PF01111) | Homo sapiens (Human) | CKS-2 |
| 3 | C (A) | 3-[({3-ethyl-5-[(2S)-2-(2-hydroxyethyl)piperidin-1-yl]pyrazolo[1,5-a]pyrimidin-7-yl}amino)methyl]-1-hydroxypyridinium | non-polymer | 397.5 | 1 | Chemie (1QK) | |||
| 4 | D, E (A, B) | water | water | 18.0 | 86 | Chemie (HOH) |
Sequence modifications
A: 1 - 297 (UniProt: P06493)
B: 1 - 79 (UniProt: P33552)
| PDB | External Database | Details |
|---|---|---|
| Gly -4 | - | expression tag |
| Pro -3 | - | expression tag |
| Leu -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly -4 | - | expression tag |
| Pro -3 | - | expression tag |
| Leu -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 44844.7 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 397.5 | |
| All* | Total formula weight | 45242.2 |
