2AST

Crystal structure of Skp1-Skp2-Cks1 in complex with a p27 peptide

Summary for 2AST

Related2ASS 1FQV
DescriptorS-phase kinase-associated protein 1A, S-phase kinase-associated protein 2, Cyclin-dependent kinases regulatory subunit 1, ... (6 entities in total)
Functional Keywordsscf-substrate complex, lrr, cell cycle, protein turnover complex, ligase-ligase inhibitor complex, ligase/ligase inhibitor
Biological sourceHomo sapiens (human)
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Cellular locationNucleus P46527
Total number of polymer chains4
Total molecular weight65908.13
Authors
Hao, B.,Zhang, N.,Schulman, B.A.,Wu, G.,Pagano, M.,Pavletich, N.P. (deposition date: 2005-08-24, release date: 2005-10-18, Last modification date: 2011-07-13)
Primary citation
Hao, B.,Zheng, N.,Schulman, B.A.,Wu, G.,Miller, J.J.,Pagano, M.,Pavletich, N.P.
Structural Basis of the Cks1-Dependent Recognition of p27(Kip1) by the SCF(Skp2) Ubiquitin Ligase.
Mol.Cell, 20:9-19, 2005
PubMed: 16209941 (PDB entries with the same primary citation)
DOI: 10.1016/j.molcel.2005.09.003
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.3 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.19541.9%4.6%9.2%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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