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2AST

Crystal structure of Skp1-Skp2-Cks1 in complex with a p27 peptide

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1AS-phase kinase-associated protein 1Apolymer15918135.31UniProt (P63208)
Pfam (PF03931)
Pfam (PF01466)
In PDB
Homo sapiens (human)Cyclin A/CDK2-associated protein p19, p19A, p19skp1, RNA polymerase II elongation factor-like protein, Organ of Corti protein 2, OCP-II protein, OCP-2, Transcription elongation factor B, SIII
2BS-phase kinase-associated protein 2polymer33637923.71UniProt (Q13309)
Pfam (PF12937)
In PDB
Homo sapiens (human)F-box protein Skp2, Cyclin A/CDK2-associated protein p45, p45skp2, F-box/LRR-repeat protein 1
3CCyclin-dependent kinases regulatory subunit 1polymer698482.71UniProt (P61024)
Pfam (PF01111)
In PDB
Homo sapiens (human)CKS-1
4DCyclin-dependent kinase inhibitor 1Bpolymer101126.21UniProt (P46527)
In PDB
Cyclin-dependent kinase inhibitor p27, p27Kip1
5B, CBENZAMIDINEnon-polymer120.22Chemie (BEN)
6waterwater18.0265Chemie (HOH)
Sequence modifications
A: 1002 - 1160 (UniProt: P63208)
PDBExternal DatabaseDetails
Ala 1002Pro 1engineered mutation
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains4
Total formula weight65667.8
Non-Polymers*Number of molecules2
Total formula weight240.3
All*Total formula weight65908.1
*Water molecules are not included.

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PDB entries from 2024-09-18

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