2AST
Crystal structure of Skp1-Skp2-Cks1 in complex with a p27 peptide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | S-phase kinase-associated protein 1A | polymer | 159 | 18135.3 | 1 | UniProt (P63208) Pfam (PF03931) Pfam (PF01466) | Homo sapiens (human) | Cyclin A/CDK2-associated protein p19, p19A, p19skp1, RNA polymerase II elongation factor-like protein, Organ of Corti protein 2, OCP-II protein, OCP-2, Transcription elongation factor B, SIII |
| 2 | B (B) | S-phase kinase-associated protein 2 | polymer | 336 | 37923.7 | 1 | UniProt (Q13309) Pfam (PF12937) | Homo sapiens (human) | F-box protein Skp2, Cyclin A/CDK2-associated protein p45, p45skp2, F-box/LRR-repeat protein 1 |
| 3 | C (C) | Cyclin-dependent kinases regulatory subunit 1 | polymer | 69 | 8482.7 | 1 | UniProt (P61024) Pfam (PF01111) | Homo sapiens (human) | CKS-1 |
| 4 | D (D) | Cyclin-dependent kinase inhibitor 1B | polymer | 10 | 1126.2 | 1 | UniProt (P46527) | Cyclin-dependent kinase inhibitor p27, p27Kip1 | |
| 5 | E, F (B, C) | BENZAMIDINE | non-polymer | 120.2 | 2 | Chemie (BEN) | |||
| 6 | G, H, I (A, B, C) | water | water | 18.0 | 265 | Chemie (HOH) |
Sequence modifications
A: 1002 - 1160 (UniProt: P63208)
| PDB | External Database | Details |
|---|---|---|
| Ala 1002 | Pro 1 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 65667.8 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 240.3 | |
| All* | Total formula weight | 65908.1 |
