2AST

Crystal structure of Skp1-Skp2-Cks1 in complex with a p27 peptide

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000209	biological_process	protein polyubiquitination
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005813	cellular_component	centrosome
A	0005829	cellular_component	cytosol
A	0006338	biological_process	chromatin remodeling
A	0006511	biological_process	ubiquitin-dependent protein catabolic process
A	0006513	biological_process	protein monoubiquitination
A	0008013	molecular_function	beta-catenin binding
A	0016567	biological_process	protein ubiquitination
A	0019005	cellular_component	SCF ubiquitin ligase complex
A	0019904	molecular_function	protein domain specific binding
A	0031146	biological_process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
A	0031467	cellular_component	Cul7-RING ubiquitin ligase complex
A	0031519	cellular_component	PcG protein complex
A	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
A	0051457	biological_process	maintenance of protein location in nucleus
A	0070936	biological_process	protein K48-linked ubiquitination
A	0097602	molecular_function	cullin family protein binding
A	0140677	molecular_function	molecular function activator activity
A	0160072	molecular_function	ubiquitin ligase complex scaffold activity
A	1990444	molecular_function	F-box domain binding
A	1990756	molecular_function	ubiquitin-like ligase-substrate adaptor activity
A	1990757	molecular_function	ubiquitin ligase activator activity
C	0016538	molecular_function	cyclin-dependent protein serine/threonine kinase regulator activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE BEN C 1001

Chain	Residue
B	PHE2169
B	VAL2192
C	HOH100
C	HOH182
C	HOH247
C	MET3058
C	ARG3070

---

site_id	AC2
Number of Residues	10
Details	BINDING SITE FOR RESIDUE BEN B 1002

Chain	Residue
B	HOH263
B	ALA2227
B	SER2230
B	SER2254
C	HIS3021
C	HIS3060
C	GLU3063
C	ILE3066
B	HOH67
B	HOH74

---

site_id	AC3
Number of Residues	14
Details	BINDING SITE FOR CHAIN D OF CYCLIN-DEPENDENT KINASE INHIBITOR 1B

Chain	Residue
B	HOH13
B	ARG2294
B	TYR2346
B	ASP2347
C	TYR3008
C	ASP3010
C	LYS3011
C	ARG3020
C	ARG3044
C	GLN3049
C	GLN3050
C	SER3051
C	GLN3052
C	TRP3054

---

Functional Information from PROSITE/UniProt

site_id	PS00944
Number of Residues	19
Details	CKS_1 Cyclin-dependent kinases regulatory subunits signature 1. YSdKYdDEeFEYRHVmLPK

Chain	Residue	Details
C	TYR3008-LYS3026

---

site_id	PS00945
Number of Residues	11
Details	CKS_2 Cyclin-dependent kinases regulatory subunits signature 2. HePEpHILLFR

Chain	Residue	Details
C	HIS3060-ARG3070

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)","evidences":[{"source":"PubMed","id":"25114211","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	25
Details	Repeat: {"description":"LRR 1","evidences":[{"source":"PubMed","id":"11099048","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	27
Details	Repeat: {"description":"LRR 2","evidences":[{"source":"PubMed","id":"11099048","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	24
Details	Repeat: {"description":"LRR 3","evidences":[{"source":"PubMed","id":"11099048","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	22
Details	Repeat: {"description":"LRR 4","evidences":[{"source":"PubMed","id":"11099048","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	26
Details	Repeat: {"description":"LRR 5","evidences":[{"source":"PubMed","id":"11099048","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	22
Details	Repeat: {"description":"LRR 6","evidences":[{"source":"PubMed","id":"11099048","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	21
Details	Repeat: {"description":"LRR 7","evidences":[{"source":"PubMed","id":"11099048","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	22
Details	Repeat: {"description":"LRR 8","evidences":[{"source":"PubMed","id":"11099048","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	19
Details	Repeat: {"description":"LRR 9","evidences":[{"source":"PubMed","id":"11099048","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	21
Details	Repeat: {"description":"LRR 10","evidences":[{"source":"PubMed","id":"11099048","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18220336","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---