2AST
Crystal structure of Skp1-Skp2-Cks1 in complex with a p27 peptide
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000209 | biological_process | protein polyubiquitination |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005813 | cellular_component | centrosome |
| A | 0005829 | cellular_component | cytosol |
| A | 0006338 | biological_process | chromatin remodeling |
| A | 0006511 | biological_process | ubiquitin-dependent protein catabolic process |
| A | 0006513 | biological_process | protein monoubiquitination |
| A | 0006915 | biological_process | apoptotic process |
| A | 0008013 | molecular_function | beta-catenin binding |
| A | 0016567 | biological_process | protein ubiquitination |
| A | 0019005 | cellular_component | SCF ubiquitin ligase complex |
| A | 0019904 | molecular_function | protein domain specific binding |
| A | 0031146 | biological_process | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process |
| A | 0031467 | cellular_component | Cul7-RING ubiquitin ligase complex |
| A | 0031519 | cellular_component | PcG protein complex |
| A | 0043161 | biological_process | proteasome-mediated ubiquitin-dependent protein catabolic process |
| A | 0051457 | biological_process | maintenance of protein location in nucleus |
| A | 0061564 | biological_process | axon development |
| A | 0070936 | biological_process | protein K48-linked ubiquitination |
| A | 0097602 | molecular_function | cullin family protein binding |
| A | 0140677 | molecular_function | molecular function activator activity |
| A | 0160072 | molecular_function | ubiquitin ligase complex scaffold activity |
| A | 1904037 | biological_process | positive regulation of epithelial cell apoptotic process |
| A | 1990444 | molecular_function | F-box domain binding |
| A | 1990756 | molecular_function | ubiquitin-like ligase-substrate adaptor activity |
| A | 1990757 | molecular_function | ubiquitin ligase activator activity |
| C | 0016538 | molecular_function | cyclin-dependent protein serine/threonine kinase regulator activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE BEN C 1001 |
| Chain | Residue |
| B | PHE2169 |
| B | VAL2192 |
| C | HOH100 |
| C | HOH182 |
| C | HOH247 |
| C | MET3058 |
| C | ARG3070 |
| site_id | AC2 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE BEN B 1002 |
| Chain | Residue |
| B | HOH263 |
| B | ALA2227 |
| B | SER2230 |
| B | SER2254 |
| C | HIS3021 |
| C | HIS3060 |
| C | GLU3063 |
| C | ILE3066 |
| B | HOH67 |
| B | HOH74 |
| site_id | AC3 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR CHAIN D OF CYCLIN-DEPENDENT KINASE INHIBITOR 1B |
| Chain | Residue |
| B | HOH13 |
| B | ARG2294 |
| B | TYR2346 |
| B | ASP2347 |
| C | TYR3008 |
| C | ASP3010 |
| C | LYS3011 |
| C | ARG3020 |
| C | ARG3044 |
| C | GLN3049 |
| C | GLN3050 |
| C | SER3051 |
| C | GLN3052 |
| C | TRP3054 |
Functional Information from PROSITE/UniProt
| site_id | PS00944 |
| Number of Residues | 19 |
| Details | CKS_1 Cyclin-dependent kinases regulatory subunits signature 1. YSdKYdDEeFEYRHVmLPK |
| Chain | Residue | Details |
| C | TYR3008-LYS3026 |
| site_id | PS00945 |
| Number of Residues | 11 |
| Details | CKS_2 Cyclin-dependent kinases regulatory subunits signature 2. HePEpHILLFR |
| Chain | Residue | Details |
| C | HIS3060-ARG3070 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine; by PKB/AKT1, CDK1 and CDK2 => ECO:0000269|PubMed:10323868, ECO:0000269|PubMed:12042314, ECO:0000269|PubMed:16209941, ECO:0000269|PubMed:23478441 |
| Chain | Residue | Details |
| D | TPO4187 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1) => ECO:0007744|PubMed:25114211 |
| Chain | Residue | Details |
| A | ASN1143 |
