8GCR
 
 | | HPV16 E6-E6AP-p53 complex | | 分子名称: | Cellular tumor antigen p53, Maltose/maltodextrin-binding periplasmic protein,Protein E6, Ubiquitin-protein ligase E3A, ... | | 著者 | Bratkowski, M.A, Wang, J.C.K, Hao, Q, Nile, A.H. | | 登録日 | 2023-03-02 | | 公開日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (3.38 Å) | | 主引用文献 | Structure of the p53 degradation complex from HPV16.
Nat Commun, 15, 2024
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8Y4Z
 | | Monomeric HERC5 HECT c-lobe structure in solution | | 分子名称: | E3 ISG15--protein ligase HERC5 | | 著者 | Dag, C, Lambert, M, Kahraman, K, Lohn, F, Lee, W, Gocenler, O, Guntert, P, Dotsch, V. | | 登録日 | 2024-01-31 | | 公開日 | 2024-02-14 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Monomeric HERC5 HECT c-lobe structure in solution
To Be Published
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8Q0N
 | | HACE1 in complex with RAC1 Q61L | | 分子名称: | E3 ubiquitin-protein ligase HACE1, GUANOSINE-5'-TRIPHOSPHATE, Ras-related C3 botulinum toxin substrate 1, ... | | 著者 | Wolter, M, Duering, J, Dienemann, C, Lorenz, S. | | 登録日 | 2023-07-28 | | 公開日 | 2024-01-10 | | 最終更新日 | 2024-02-28 | | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | | 主引用文献 | Structural mechanisms of autoinhibition and substrate recognition by the ubiquitin ligase HACE1.
Nat.Struct.Mol.Biol., 31, 2024
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8PWL
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8R1G
 | | Dimeric ternary structure of E6AP-E6-p53 | | 分子名称: | Cellular tumor antigen p53, Ubiquitin-like protein SMT3,Protein E6, Ubiquitin-protein ligase E3A, ... | | 著者 | Sandate, C.R, Chakrabory, D, Kater, L, Kempf, G, Thoma, N.H. | | 登録日 | 2023-11-01 | | 公開日 | 2023-12-06 | | 実験手法 | ELECTRON MICROSCOPY (3.99 Å) | | 主引用文献 | Monomeric E6AP-E6-p53 ternary complex
To Be Published
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8R1F
 | | Monomeric E6AP-E6-p53 ternary complex | | 分子名称: | Cellular tumor antigen p53, Ubiquitin-like protein SMT3,Protein E6, Ubiquitin-protein ligase E3A, ... | | 著者 | Sandate, C.R, Chakraborty, D, Kater, L, Kempf, G, Thoma, N.H. | | 登録日 | 2023-11-01 | | 公開日 | 2023-12-06 | | 実験手法 | ELECTRON MICROSCOPY (3.67 Å) | | 主引用文献 | Monomeric E6AP-E6-p53 ternary complex
To Be Published
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8EI7
 | | Crystal structure of the WWP2 HECT domain in complex with H304, a Helicon Polypeptide | | 分子名称: | 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... | | 著者 | Li, K, Tokareva, O.S, Thomson, T.M, Verdine, G.L, McGee, J.H. | | 登録日 | 2022-09-14 | | 公開日 | 2023-10-25 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.22 Å) | | 主引用文献 | Recognition and reprogramming of E3 ubiquitin ligase surfaces by alpha-helical peptides.
Nat Commun, 14, 2023
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8EI6
 | | Crystal structure of the WWP2 HECT domain in complex with H305, a Helicon Polypeptide | | 分子名称: | H305, N,N'-(1,4-phenylene)diacetamide, NEDD4-like E3 ubiquitin-protein ligase WWP2 | | 著者 | Li, K, Tokareva, O.S, Thomson, T.M, Verdine, G.L, McGee, J.H. | | 登録日 | 2022-09-14 | | 公開日 | 2023-10-25 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (3.62 Å) | | 主引用文献 | Recognition and reprogramming of E3 ubiquitin ligase surfaces by alpha-helical peptides.
Nat Commun, 14, 2023
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8EI8
 | | Crystal structure of the WWP2 HECT domain in complex with H308, a Helicon Polypeptide | | 分子名称: | 1,2-ETHANEDIOL, H308, N,N'-(1,4-phenylene)diacetamide, ... | | 著者 | Li, K, Tokareva, O.S, Thomson, T.M, Verdine, G.L, McGee, J.H. | | 登録日 | 2022-09-14 | | 公開日 | 2023-10-25 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Recognition and reprogramming of E3 ubiquitin ligase surfaces by alpha-helical peptides.
Nat Commun, 14, 2023
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8EI4
 | | Crystal structure of the WWP1 HECT domain in complex with H302, a Helicon Polypeptide | | 分子名称: | 1,2-ETHANEDIOL, H302, N,N'-(1,4-phenylene)diacetamide, ... | | 著者 | Li, K, Tokareva, O.S, Thomson, T.M, Verdine, G.L, McGee, J.H. | | 登録日 | 2022-09-14 | | 公開日 | 2023-10-25 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.43 Å) | | 主引用文献 | Recognition and reprogramming of E3 ubiquitin ligase surfaces by alpha-helical peptides.
Nat Commun, 14, 2023
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8EI5
 | | Crystal structure of the WWP2 HECT domain in complex with H301, a Helicon Polypeptide | | 分子名称: | 1,2-ETHANEDIOL, GLYCEROL, H301, ... | | 著者 | Li, K, Tokareva, O.S, Thomson, T.M, Verdine, G.L, McGee, J.H. | | 登録日 | 2022-09-14 | | 公開日 | 2023-10-25 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Recognition and reprogramming of E3 ubiquitin ligase surfaces by alpha-helical peptides.
Nat Commun, 14, 2023
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7QPB
 | | Catalytic C-lobe of the HECT-type ubiquitin ligase E6AP in complex with a hybrid foldamer-peptide macrocycle | | 分子名称: | Isoform I of Ubiquitin-protein ligase E3A, hybrid foldamer-peptide macrocycle | | 著者 | Dengler, S, Howard, R.T, Morozov, V, Tsiamantas, C, Douat, C, Suga, H, Huc, I. | | 登録日 | 2022-01-03 | | 公開日 | 2023-09-27 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.342 Å) | | 主引用文献 | Display Selection of a Hybrid Foldamer-Peptide Macrocycle.
Angew.Chem.Int.Ed.Engl., 62, 2023
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8C07
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8C06
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8BJA
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8HAE
 | | Cryo-EM structure of HACE1 dimer | | 分子名称: | E3 ubiquitin-protein ligase HACE1 | | 著者 | Singh, S, Machida, S, Tulsian, N.K, Choong, Y.K, Ng, J, Shanker, S, Yaochen, L.D, Shi, J, Sivaraman, J, Machida, S. | | 登録日 | 2022-10-26 | | 公開日 | 2023-06-28 | | 最終更新日 | 2023-10-04 | | 実験手法 | ELECTRON MICROSCOPY (4.55 Å) | | 主引用文献 | Structural Basis for the Enzymatic Activity of the HACE1 HECT-Type E3 Ligase Through N-Terminal Helix Dimerization.
Adv Sci, 10, 2023
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8H8X
 | | Cryo-EM structure of HACE1 monomer | | 分子名称: | E3 ubiquitin-protein ligase HACE1 | | 著者 | Singh, S, Machida, S, Tulsian, N.K, Choong, Y.K, Ng, J, Shanker, S, Yaochen, L.D, Shi, J, Sivaraman, J. | | 登録日 | 2022-10-24 | | 公開日 | 2023-06-28 | | 最終更新日 | 2024-01-10 | | 実験手法 | ELECTRON MICROSCOPY (3.92 Å) | | 主引用文献 | Structural Basis for the Enzymatic Activity of the HACE1 HECT-Type E3 Ligase Through N-Terminal Helix Dimerization.
Adv Sci, 10, 2023
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8P82
 | | Cryo-EM structure of dimeric UBR5 | | 分子名称: | E3 ubiquitin-protein ligase UBR5, ZINC ION | | 著者 | Aguirre, J.D, Kater, L, Kempf, G, Cavadini, S, Thoma, N.H. | | 登録日 | 2023-05-31 | | 公開日 | 2023-06-14 | | 実験手法 | ELECTRON MICROSCOPY (3.36 Å) | | 主引用文献 | UBR5 forms ligand-dependent complexes on chromatin to regulate nuclear hormone receptor stability
To Be Published
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8P83
 | | Cryo-EM structure of full-length human UBR5 (homotetramer) | | 分子名称: | E3 ubiquitin-protein ligase UBR5 | | 著者 | Aguirre, J.D, Kater, L, Kempf, G, Cavadini, S, Thoma, N.H. | | 登録日 | 2023-05-31 | | 公開日 | 2023-06-14 | | 最終更新日 | 2023-08-16 | | 実験手法 | ELECTRON MICROSCOPY (3.87 Å) | | 主引用文献 | UBR5 forms ligand-dependent complexes on chromatin to regulate nuclear hormone receptor stability.
Mol.Cell, 83, 2023
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8E0Q
 | | Structure of the human UBR5 HECT-type E3 ubiquitin ligase in a C2 symmetric dimeric form | | 分子名称: | E3 ubiquitin-protein ligase UBR5, ZINC ION | | 著者 | Wang, F, He, Q, Lin, G, Li, H. | | 登録日 | 2022-08-09 | | 公開日 | 2023-04-19 | | 最終更新日 | 2023-05-17 | | 実験手法 | ELECTRON MICROSCOPY (2.66 Å) | | 主引用文献 | Structure of the human UBR5 E3 ubiquitin ligase.
Structure, 31, 2023
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8EWI
 | | Structure of the human UBR5 HECT-type E3 ubiquitin ligase in a tetrameric form | | 分子名称: | E3 ubiquitin-protein ligase UBR5, ZINC ION | | 著者 | Wang, F, He, Q, Lin, G, Li, H. | | 登録日 | 2022-10-23 | | 公開日 | 2023-04-19 | | 最終更新日 | 2023-05-17 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | Structure of the human UBR5 E3 ubiquitin ligase.
Structure, 31, 2023
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8D4X
 | | Structure of the human UBR5 HECT-type E3 ubiquitin ligase in a dimeric form | | 分子名称: | E3 ubiquitin-protein ligase UBR5, ZINC ION | | 著者 | Wang, F, He, Q, Lin, G, Li, H. | | 登録日 | 2022-06-02 | | 公開日 | 2023-04-19 | | 最終更新日 | 2023-05-17 | | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | | 主引用文献 | Structure of the human UBR5 E3 ubiquitin ligase.
Structure, 31, 2023
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7NH3
 | | Nematocida Huwe1 in open conformation. | | 分子名称: | E3 ubiquitin-protein ligase HUWE1 | | 著者 | Petrova, O, Grishkovskaya, I, Grabarczyk, D.B, Kessler, D, Haselbach, D, Clausen, T. | | 登録日 | 2021-02-09 | | 公開日 | 2022-03-02 | | 最終更新日 | 2023-07-26 | | 実験手法 | ELECTRON MICROSCOPY (6.37 Å) | | 主引用文献 | Crystal structure of HUWE1: One ring to ubiquitinate them all
To Be Published
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6XZ1
 | | Conjugate of the HECT domain of HUWE1 with ubiquitin | | 分子名称: | HECT, UBA and WWE domain containing 1, isoform CRA_a, ... | | 著者 | Liu, B, Seenivasan, A, Nair, R, Chen, D, Lowe, E.D, Lorenz, S. | | 登録日 | 2020-01-31 | | 公開日 | 2021-08-25 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Reconstitution and Structural Analysis of a HECT Ligase-Ubiquitin Complex via an Activity-Based Probe.
Acs Chem.Biol., 16, 2021
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7MWD
 | | HUWE1 in map with focus on HECT | | 分子名称: | E3 ubiquitin-protein ligase HUWE1 | | 著者 | Hunkeler, M, Fischer, E.S. | | 登録日 | 2021-05-16 | | 公開日 | 2021-07-28 | | 最終更新日 | 2021-09-15 | | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | | 主引用文献 | Solenoid architecture of HUWE1 contributes to ligase activity and substrate recognition.
Mol.Cell, 81, 2021
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