7QPB
Catalytic C-lobe of the HECT-type ubiquitin ligase E6AP in complex with a hybrid foldamer-peptide macrocycle
Summary for 7QPB
Entry DOI | 10.2210/pdb7qpb/pdb |
Descriptor | Isoform I of Ubiquitin-protein ligase E3A, hybrid foldamer-peptide macrocycle (3 entities in total) |
Functional Keywords | hect, e3 ligase catalytic domain, ubiquitin protein ligase, transferase activity, catalytic activity, ligase |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 6 |
Total formula weight | 56113.89 |
Authors | Dengler, S.,Howard, R.T.,Morozov, V.,Tsiamantas, C.,Douat, C.,Suga, H.,Huc, I. (deposition date: 2022-01-03, release date: 2023-09-27, Last modification date: 2024-07-10) |
Primary citation | Dengler, S.,Howard, R.T.,Morozov, V.,Tsiamantas, C.,Huang, W.E.,Liu, Z.,Dobrzanski, C.,Pophristic, V.,Brameyer, S.,Douat, C.,Suga, H.,Huc, I. Display Selection of a Hybrid Foldamer-Peptide Macrocycle. Angew.Chem.Int.Ed.Engl., 62:e202308408-e202308408, 2023 Cited by PubMed: 37707879DOI: 10.1002/anie.202308408 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.342 Å) |
Structure validation
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