7QPB

Catalytic C-lobe of the HECT-type ubiquitin ligase E6AP in complex with a hybrid foldamer-peptide macrocycle

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000209	biological_process	protein polyubiquitination
A	0004842	molecular_function	ubiquitin-protein transferase activity
A	0061630	molecular_function	ubiquitin protein ligase activity
B	0000209	biological_process	protein polyubiquitination
B	0004842	molecular_function	ubiquitin-protein transferase activity
B	0061630	molecular_function	ubiquitin protein ligase activity
C	0000209	biological_process	protein polyubiquitination
C	0004842	molecular_function	ubiquitin-protein transferase activity
C	0061630	molecular_function	ubiquitin protein ligase activity
D	0000209	biological_process	protein polyubiquitination
D	0004842	molecular_function	ubiquitin-protein transferase activity
D	0061630	molecular_function	ubiquitin protein ligase activity

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Active site: {"description":"Glycyl thioester intermediate"}

Chain

Residue

Details

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Catalytic Information from CSA

site_id	MCSA1
Number of Residues	2
Details	M-CSA 438

Chain	Residue	Details
A	HIS818
A	CYS820	covalent catalysis

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site_id	MCSA2
Number of Residues	2
Details	M-CSA 438

Chain	Residue	Details
B	HIS818
B	CYS820	covalent catalysis

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site_id	MCSA3
Number of Residues	2
Details	M-CSA 438

Chain	Residue	Details
C	HIS818
C	CYS820	covalent catalysis

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site_id	MCSA4
Number of Residues	2
Details	M-CSA 438

Chain	Residue	Details
D	HIS818
D	CYS820	covalent catalysis

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