7QPB
Catalytic C-lobe of the HECT-type ubiquitin ligase E6AP in complex with a hybrid foldamer-peptide macrocycle
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Isoform I of Ubiquitin-protein ligase E3A | polymer | 114 | 12961.8 | 4 | UniProt (Q05086) Pfam (PF00632) | Homo sapiens (human) | E6AP ubiquitin-protein ligase,HECT-type ubiquitin transferase E3A,Human papillomavirus E6-associated protein,Oncogenic protein-associated protein E6-AP,Renal carcinoma antigen NY-REN-54 |
| 2 | E, F (H, I) | hybrid foldamer-peptide macrocycle | polymer | 15 | 2133.4 | 2 | synthetic construct | ||
| 3 | G, H, I, J, K (A, B, C, D, H) | water | water | 18.0 | 57 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 741 - 852 (UniProt: Q05086)
| PDB | External Database | Details |
|---|---|---|
| Gly 739 | - | expression tag |
| Pro 740 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 56113.9 | |
| All* | Total formula weight | 56113.9 |
