8EI4

Crystal structure of the WWP1 HECT domain in complex with H302, a Helicon Polypeptide

Summary for 8EI4

• Entry DOI: 10.2210/pdb8ei4/pdb
• Descriptor: NEDD4-like E3 ubiquitin-protein ligase WWP1, H302, 1,2-ETHANEDIOL, ... (5 entities in total)
• Functional Keywords: e3 ligase, complex, stapled peptide, ligase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 46766.64

Authors

Li, K.,Tokareva, O.S.,Thomson, T.M.,Verdine, G.L.,McGee, J.H. (deposition date: 2022-09-14, release date: 2023-10-25, Last modification date: 2023-11-15)

• Primary citation: Tokareva, O.S.,Li, K.,Travaline, T.L.,Thomson, T.M.,Swiecicki, J.M.,Moussa, M.,Ramirez, J.D.,Litchman, S.,Verdine, G.L.,McGee, J.H.; Recognition and reprogramming of E3 ubiquitin ligase surfaces by alpha-helical peptides.; Nat Commun, 14:6992-6992, 2023; PubMed: 37914719; DOI: 10.1038/s41467-023-42395-z

Experimental method

X-RAY DIFFRACTION (2.43 Å)