7BII
| Crystal structure of Nematocida HUWE1 | Descriptor: | E3 ubiquitin-protein ligase HUWE1 | Authors: | Grabarczyk, D.B, Petrova, O.A, Meinhart, A, Kessler, D, Clausen, T. | Deposit date: | 2021-01-12 | Release date: | 2021-07-28 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (3.037 Å) | Cite: | HUWE1 employs a giant substrate-binding ring to feed and regulate its HECT E3 domain. Nat.Chem.Biol., 17, 2021
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8C06
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8BJA
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8D4X
| Structure of the human UBR5 HECT-type E3 ubiquitin ligase in a dimeric form | Descriptor: | E3 ubiquitin-protein ligase UBR5, ZINC ION | Authors: | Wang, F, He, Q, Lin, G, Li, H. | Deposit date: | 2022-06-02 | Release date: | 2023-04-19 | Last modified: | 2023-05-17 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Structure of the human UBR5 E3 ubiquitin ligase. Structure, 31, 2023
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7NH3
| Nematocida Huwe1 in open conformation. | Descriptor: | E3 ubiquitin-protein ligase HUWE1 | Authors: | Petrova, O, Grishkovskaya, I, Grabarczyk, D.B, Kessler, D, Haselbach, D, Clausen, T. | Deposit date: | 2021-02-09 | Release date: | 2022-03-02 | Last modified: | 2023-07-26 | Method: | ELECTRON MICROSCOPY (6.37 Å) | Cite: | Crystal structure of HUWE1: One ring to ubiquitinate them all To Be Published
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8P82
| Cryo-EM structure of dimeric UBR5 | Descriptor: | E3 ubiquitin-protein ligase UBR5, ZINC ION | Authors: | Aguirre, J.D, Kater, L, Kempf, G, Cavadini, S, Thoma, N.H. | Deposit date: | 2023-05-31 | Release date: | 2023-06-14 | Method: | ELECTRON MICROSCOPY (3.36 Å) | Cite: | UBR5 forms ligand-dependent complexes on chromatin to regulate nuclear hormone receptor stability To Be Published
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8P83
| Cryo-EM structure of full-length human UBR5 (homotetramer) | Descriptor: | E3 ubiquitin-protein ligase UBR5 | Authors: | Aguirre, J.D, Kater, L, Kempf, G, Cavadini, S, Thoma, N.H. | Deposit date: | 2023-05-31 | Release date: | 2023-06-14 | Last modified: | 2023-08-16 | Method: | ELECTRON MICROSCOPY (3.87 Å) | Cite: | UBR5 forms ligand-dependent complexes on chromatin to regulate nuclear hormone receptor stability. Mol.Cell, 83, 2023
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8PWL
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8E0Q
| Structure of the human UBR5 HECT-type E3 ubiquitin ligase in a C2 symmetric dimeric form | Descriptor: | E3 ubiquitin-protein ligase UBR5, ZINC ION | Authors: | Wang, F, He, Q, Lin, G, Li, H. | Deposit date: | 2022-08-09 | Release date: | 2023-04-19 | Last modified: | 2023-05-17 | Method: | ELECTRON MICROSCOPY (2.66 Å) | Cite: | Structure of the human UBR5 E3 ubiquitin ligase. Structure, 31, 2023
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8EWI
| Structure of the human UBR5 HECT-type E3 ubiquitin ligase in a tetrameric form | Descriptor: | E3 ubiquitin-protein ligase UBR5, ZINC ION | Authors: | Wang, F, He, Q, Lin, G, Li, H. | Deposit date: | 2022-10-23 | Release date: | 2023-04-19 | Last modified: | 2023-05-17 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Structure of the human UBR5 E3 ubiquitin ligase. Structure, 31, 2023
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8HAE
| Cryo-EM structure of HACE1 dimer | Descriptor: | E3 ubiquitin-protein ligase HACE1 | Authors: | Singh, S, Machida, S, Tulsian, N.K, Choong, Y.K, Ng, J, Shanker, S, Yaochen, L.D, Shi, J, Sivaraman, J, Machida, S. | Deposit date: | 2022-10-26 | Release date: | 2023-06-28 | Last modified: | 2023-10-04 | Method: | ELECTRON MICROSCOPY (4.55 Å) | Cite: | Structural Basis for the Enzymatic Activity of the HACE1 HECT-Type E3 Ligase Through N-Terminal Helix Dimerization. Adv Sci, 10, 2023
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8H8X
| Cryo-EM structure of HACE1 monomer | Descriptor: | E3 ubiquitin-protein ligase HACE1 | Authors: | Singh, S, Machida, S, Tulsian, N.K, Choong, Y.K, Ng, J, Shanker, S, Yaochen, L.D, Shi, J, Sivaraman, J. | Deposit date: | 2022-10-24 | Release date: | 2023-06-28 | Last modified: | 2024-01-10 | Method: | ELECTRON MICROSCOPY (3.92 Å) | Cite: | Structural Basis for the Enzymatic Activity of the HACE1 HECT-Type E3 Ligase Through N-Terminal Helix Dimerization. Adv Sci, 10, 2023
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5XMC
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6XZ1
| Conjugate of the HECT domain of HUWE1 with ubiquitin | Descriptor: | HECT, UBA and WWE domain containing 1, isoform CRA_a, ... | Authors: | Liu, B, Seenivasan, A, Nair, R, Chen, D, Lowe, E.D, Lorenz, S. | Deposit date: | 2020-01-31 | Release date: | 2021-08-25 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Reconstitution and Structural Analysis of a HECT Ligase-Ubiquitin Complex via an Activity-Based Probe. Acs Chem.Biol., 16, 2021
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4LCD
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1C4Z
| STRUCTURE OF AN E6AP-UBCH7 COMPLEX: INSIGHTS INTO THE UBIQUITINATION PATHWAY | Descriptor: | UBIQUITIN CONJUGATING ENZYME E2, UBIQUITIN-PROTEIN LIGASE E3A | Authors: | Huang, L, Kinnucan, E, Wang, G, Beaudenon, S, Howley, P.M, Huibregtse, J.M, Pavletich, N.P. | Deposit date: | 1999-10-14 | Release date: | 1999-11-17 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structure of an E6AP-UbcH7 complex: insights into ubiquitination by the E2-E3 enzyme cascade. Science, 286, 1999
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7JQ9
| Cryo-EM structure of human HUWE1 | Descriptor: | E3 ubiquitin-protein ligase HUWE1 | Authors: | Hunkeler, M, Fischer, E.S. | Deposit date: | 2020-08-10 | Release date: | 2021-07-28 | Last modified: | 2021-09-15 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Solenoid architecture of HUWE1 contributes to ligase activity and substrate recognition. Mol.Cell, 81, 2021
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4BBN
| NEDD4 HECT-Ub:Ub complex | Descriptor: | E3 UBIQUITIN-PROTEIN LIGASE NEDD4, POLYUBIQUITIN-B | Authors: | Maspero, E, Valentini, E, Mari, S, Cecatiello, V, Polo, S, Pasqualato, S. | Deposit date: | 2012-09-27 | Release date: | 2013-05-01 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.51 Å) | Cite: | Structure of a Ubiquitin-Loaded Hect Ligase Reveals the Molecular Basis for Catalytic Priming Nat.Struct.Mol.Biol., 20, 2013
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2XBB
| Nedd4 HECT:Ub complex | Descriptor: | E3 UBIQUITIN-PROTEIN LIGASE NEDD4, GLYCEROL, UBIQUITIN | Authors: | Maspero, E, Cecatiello, V, Musacchio, A, Polo, S, Pasqualato, S. | Deposit date: | 2010-04-08 | Release date: | 2011-03-23 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.68 Å) | Cite: | Structure of the Hect:Ubiquitin Complex and its Role in Ubiquitin Chain Elongation Embo Rep., 12, 2011
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6FYH
| Disulfide between ubiquitin G76C and the E3 HECT ligase Huwe1 | Descriptor: | E3 ubiquitin-protein ligase HUWE1, Polyubiquitin-B, SULFATE ION, ... | Authors: | Jaeckl, M, Hartmann, M.D, Wiesner, S. | Deposit date: | 2018-03-12 | Release date: | 2018-07-11 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.906 Å) | Cite: | beta-Sheet Augmentation Is a Conserved Mechanism of Priming HECT E3 Ligases for Ubiquitin Ligation. J. Mol. Biol., 430, 2018
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3OLM
| Structure and Function of a Ubiquitin Binding Site within the Catalytic Domain of a HECT Ubiquitin Ligase | Descriptor: | E3 ubiquitin-protein ligase RSP5, Ubiquitin | Authors: | Kim, H.C, Steffen, A, Chen, J, Huibregtse, J.M. | Deposit date: | 2010-08-26 | Release date: | 2011-03-23 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.495 Å) | Cite: | Structure and function of a HECT domain ubiquitin-binding site. Embo Rep., 12, 2011
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6FX4
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7M3Q
| Structure of the Smurf2 HECT Domain with a High Affinity Ubiquitin Variant (UbV) | Descriptor: | 1,2-ETHANEDIOL, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, CHLORIDE ION, ... | Authors: | Chowdhury, A, Singer, A.U, Ogunjimi, A.A, Teyra, J, Zhang, W, Sicheri, F, Sidhu, S.S. | Deposit date: | 2021-03-18 | Release date: | 2021-04-21 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structure of the Smurf2 HECT Domain with a High Affinity Ubiquitin Variant (UbV) To be published
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5C7M
| CRYSTAL STRUCTURE OF E3 LIGASE ITCH WITH A UB VARIANT | Descriptor: | E3 ubiquitin-protein ligase Itchy homolog, Polyubiquitin-C | Authors: | Walker, J.R, Hu, J, Dong, A, Wernimont, A, Zhang, W, Sidhu, S, Bountra, C, Edwards, A.M, Arrowsmith, C.H, Tong, Y, Structural Genomics Consortium (SGC) | Deposit date: | 2015-06-24 | Release date: | 2016-03-16 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (3.03 Å) | Cite: | System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes. Mol.Cell, 62, 2016
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5C7J
| CRYSTAL STRUCTURE OF NEDD4 WITH A UB VARIANT | Descriptor: | E3 ubiquitin-protein ligase NEDD4, Polyubiquitin-C | Authors: | Walker, J.R, Hu, J, Dong, A, Bountra, C, Edwards, A.M, Arrowsmith, C.H, Tong, Y, Structural Genomics Consortium (SGC) | Deposit date: | 2015-06-24 | Release date: | 2016-03-16 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes. Mol.Cell, 62, 2016
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