PDB: 861 件ウェブページステータス検索Chemie searchBIRD

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7BZ2	Cryo-EM structure of the formoterol-bound beta2 adrenergic receptor-Gs protein complex. 分子名称: Beta2 adrenergic receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Zhang, Y.N, Yang, F, Ling, S.L, Lv, P, Zhou, Y.X, Fang, W, Sun, W, Shi, P, Tian, C.L. 登録日 2020-04-26 公開日 2020-08-05 実験手法 ELECTRON MICROSCOPY (3.82 Å) 主引用文献 Single-particle cryo-EM structural studies of the beta2AR-Gs complex bound with a full agonist formoterol. Cell Discov, 6, 2020
6UUS	CryoEM Structure of the active Adrenomedullin 2 receptor G protein complex with adrenomedullin peptide 分子名称: ADM, Calcitonin gene-related peptide type 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Belousoff, M.J, Liang, Y.L, Sexton, P, Danev, R. 登録日 2019-10-31 公開日 2020-04-01 最終更新日 2020-04-29 実験手法 ELECTRON MICROSCOPY (2.4 Å) 主引用文献 Structure and Dynamics of Adrenomedullin Receptors AM1and AM2Reveal Key Mechanisms in the Control of Receptor Phenotype by Receptor Activity-Modifying Proteins. Acs Pharmacol Transl Sci, 3, 2020
6UVA	CryoEM Structure of the active Adrenomedullin 2 receptor G protein complex with adrenomedullin 2 peptide 分子名称: Calcitonin gene-related peptide type 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Belousoff, M.J, Liang, Y.L, Sexton, P, Danev, R. 登録日 2019-11-01 公開日 2020-04-01 最終更新日 2020-04-29 実験手法 ELECTRON MICROSCOPY (2.3 Å) 主引用文献 Structure and Dynamics of Adrenomedullin Receptors AM1and AM2Reveal Key Mechanisms in the Control of Receptor Phenotype by Receptor Activity-Modifying Proteins. Acs Pharmacol Transl Sci, 3, 2020
6UUN	CryoEM Structure of the active Adrenomedullin 1 receptor G protein complex with adrenomedullin peptide 分子名称: ADM, Calcitonin gene-related peptide type 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Belousoff, M.J, Liang, Y.L, Sexton, P, Danev, R. 登録日 2019-10-30 公開日 2020-03-25 最終更新日 2020-04-29 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Structure and Dynamics of Adrenomedullin Receptors AM1and AM2Reveal Key Mechanisms in the Control of Receptor Phenotype by Receptor Activity-Modifying Proteins. Acs Pharmacol Transl Sci, 3, 2020
3AH8	Structure of heterotrimeric G protein Galpha-q beta gamma in complex with an inhibitor YM-254890 分子名称: GUANOSINE-5'-DIPHOSPHATE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Nishimura, A, Kitano, K, Takasaki, J, Taniguchi, M, Mizuno, N, Tago, K, Hakoshima, T, Itoh, H. 登録日 2010-04-20 公開日 2010-07-21 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Structural basis for the specific inhibition of heterotrimeric Gq protein by a small molecule. Proc.Natl.Acad.Sci.USA, 107, 2010
1AZS	COMPLEX OF GS-ALPHA WITH THE CATALYTIC DOMAINS OF MAMMALIAN ADENYLYL CYCLASE 分子名称: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, GS-ALPHA, IIC2, ... 著者 Tesmer, J.J.G, Sprang, S.R. 登録日 1997-11-20 公開日 1998-02-25 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Crystal structure of the catalytic domains of adenylyl cyclase in a complex with Gsalpha.GTPgammaS. Science, 278, 1997
1CJV	COMPLEX OF GS-ALPHA WITH THE CATALYTIC DOMAINS OF MAMMALIAN ADENYLYL CYCLASE: COMPLEX WITH BETA-L-2',3'-DIDEOXYATP, MG, AND ZN 分子名称: 2',3'-DIDEOXYADENOSINE-5'-TRIPHOSPHATE, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, ... 著者 Tesmer, J.J.G, Sprang, S.R. 登録日 1999-04-19 公開日 1999-08-31 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Two-metal-Ion catalysis in adenylyl cyclase. Science, 285, 1999
1CJT	COMPLEX OF GS-ALPHA WITH THE CATALYTIC DOMAINS OF MAMMALIAN ADENYLYL CYCLASE: COMPLEX WITH BETA-L-2',3'-DIDEOXYATP, MN, AND MG 分子名称: 2',3'-DIDEOXYADENOSINE-5'-TRIPHOSPHATE, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, ... 著者 Tesmer, J.J.G, Sprang, S.R. 登録日 1999-04-16 公開日 1999-08-31 最終更新日 2023-08-02 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Two-metal-Ion catalysis in adenylyl cyclase. Science, 285, 1999
1CJK	COMPLEX OF GS-ALPHA WITH THE CATALYTIC DOMAINS OF MAMMALIAN ADENYLYL CYCLASE: COMPLEX WITH ADENOSINE 5'-(ALPHA THIO)-TRIPHOSPHATE (RP), MG, AND MN 分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, ADENOSINE-5'-RP-ALPHA-THIO-TRIPHOSPHATE, ... 著者 Tesmer, J.J.G, Sprang, S.R. 登録日 1999-04-16 公開日 1999-08-31 最終更新日 2023-08-09 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Two-metal-Ion catalysis in adenylyl cyclase. Science, 285, 1999
1CS4	COMPLEX OF GS-ALPHA WITH THE CATALYTIC DOMAINS OF MAMMALIAN ADENYLYL CYCLASE: COMPLEX WITH 2'-DEOXY-ADENOSINE 3'-MONOPHOSPHATE, PYROPHOSPHATE AND MG 分子名称: 2'-DEOXY-ADENOSINE 3'-MONOPHOSPHATE, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, ... 著者 Tesmer, J.J.G, Dessauer, C.A, Sunahara, R.K, Johnson, R.A, Gilman, A.G, Sprang, S.R. 登録日 1999-08-16 公開日 2001-01-10 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Molecular basis for P-site inhibition of adenylyl cyclase. Biochemistry, 39, 2000
1CJU	COMPLEX OF GS-ALPHA WITH THE CATALYTIC DOMAINS OF MAMMALIAN ADENYLYL CYCLASE: COMPLEX WITH BETA-L-2',3'-DIDEOXYATP AND MG 分子名称: 2',3'-DIDEOXYADENOSINE-5'-TRIPHOSPHATE, 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, ADENYLATE CYCLASE, ... 著者 Tesmer, J.J.G, Sprang, S.R. 登録日 1999-04-16 公開日 1999-08-31 最終更新日 2023-08-02 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Two-metal-Ion catalysis in adenylyl cyclase. Science, 285, 1999
1CUL	COMPLEX OF GS-ALPHA WITH THE CATALYTIC DOMAINS OF MAMMALIAN ADENYLYL CYCLASE: COMPLEX WITH 2',5'-DIDEOXY-ADENOSINE 3'-TRIPHOSPHATE AND MG 分子名称: 2',5'-DIDEOXY-ADENOSINE 3'-MONOPHOSPHATE, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, ... 著者 Tesmer, J.J.G, Dessauer, C.A, Sunahara, R.K, Johnson, R.A, Gilman, A.G, Sprang, S.R. 登録日 1999-08-20 公開日 2001-01-10 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Molecular basis for P-site inhibition of adenylyl cyclase. Biochemistry, 39, 2000
1TL7	Complex Of Gs- With The Catalytic Domains Of Mammalian Adenylyl Cyclase: Complex With 2'(3')-O-(N-methylanthraniloyl)-guanosine 5'-triphosphate and Mn 分子名称: 3'-O-(N-METHYLANTHRANILOYL)-GUANOSINE-5'-TRIPHOSPHATE, 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, Adenylate cyclase, ... 著者 Mou, T.C, Gille, A, Seifert, R.J, Sprang, S.R. 登録日 2004-06-09 公開日 2004-12-14 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Structural basis for the inhibition of mammalian membrane adenylyl cyclase by 2 '(3')-O-(N-Methylanthraniloyl)-guanosine 5 '-triphosphate. J.Biol.Chem., 280, 2005
1U0H	STRUCTURAL BASIS FOR THE INHIBITION OF MAMMALIAN ADENYLYL CYCLASE BY MANT-GTP 分子名称: 3'-O-(N-METHYLANTHRANILOYL)-GUANOSINE-5'-TRIPHOSPHATE, 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, Adenylate cyclase, ... 著者 Mou, T.C, Gille, A, Seifert, R.J, Sprang, S.R. 登録日 2004-07-13 公開日 2004-12-14 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Structural basis for the inhibition of mammalian membrane adenylyl cyclase by 2 '(3')-O-(N-Methylanthraniloyl)-guanosine 5 '-triphosphate. J.Biol.Chem., 280, 2005
7YFC	Cryo-EM structure of the histamine-bound histamine H4 receptor and Gq complex 分子名称: CHOLESTEROL, Engineered G-alpha-q, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Im, D, Iwata, S, Asada, H. 登録日 2022-07-08 公開日 2023-10-25 最終更新日 2024-05-08 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Structural insights into the agonists binding and receptor selectivity of human histamine H 4 receptor. Nat Commun, 14, 2023
7YFD	Cryo-EM structure of the imetit-bound histamine H4 receptor and Gq complex 分子名称: 2-(1~{H}-imidazol-5-yl)ethyl carbamimidothioate, CHOLESTEROL, Engineered G-alpha-q, ... 著者 Im, D, Iwata, S, Asada, H. 登録日 2022-07-08 公開日 2023-10-25 最終更新日 2024-05-08 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Structural insights into the agonists binding and receptor selectivity of human histamine H 4 receptor. Nat Commun, 14, 2023
7NA7	Structures of human ghrelin receptor-Gi complexes with ghrelin and a synthetic agonist 分子名称: Antibody fragment, CHOLESTEROL, Ghrelin-27, ... 著者 Liu, H, Sun, D, Sun, J, Zhang, C. 登録日 2021-06-20 公開日 2021-12-15 実験手法 ELECTRON MICROSCOPY (2.7 Å) 主引用文献 Structural basis of human ghrelin receptor signaling by ghrelin and the synthetic agonist ibutamoren Nat Commun, 12, 2021
7NA8	Structures of human ghrelin receptor-Gi complexes with ghrelin and a synthetic agonist 分子名称: 1-(methanesulfonyl)-1'-(2-methyl-L-alanyl-O-benzyl-D-seryl)-1,2-dihydrospiro[indole-3,4'-piperidine], Antibody fragment, CHOLESTEROL, ... 著者 Liu, H, Sun, D, Sun, J, Zhang, C. 登録日 2021-06-20 公開日 2021-12-15 実験手法 ELECTRON MICROSCOPY (2.7 Å) 主引用文献 Structural basis of human ghrelin receptor signaling by ghrelin and the synthetic agonist ibutamoren Nat Commun, 12, 2021
7YU3	Human Lysophosphatidic Acid Receptor 1-Gi complex bound to ONO-0740556 分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... 著者 Akasaka, H, Shihoya, W, Nureki, O. 登録日 2022-08-16 公開日 2022-10-05 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 Structure of the active G i -coupled human lysophosphatidic acid receptor 1 complexed with a potent agonist. Nat Commun, 13, 2022
7YU5	Human Lysophosphatidic Acid Receptor 1-Gi complex bound to ONO-0740556, state1 分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... 著者 Akasaka, H, Shihoya, W, Nureki, O. 登録日 2022-08-16 公開日 2022-10-05 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Structure of the active G i -coupled human lysophosphatidic acid receptor 1 complexed with a potent agonist. Nat Commun, 13, 2022
7YU7	Human Lysophosphatidic Acid Receptor 1-Gi complex bound to ONO-0740556, state3 分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... 著者 Akasaka, H, Shihoya, W, Nureki, O. 登録日 2022-08-16 公開日 2022-10-05 実験手法 ELECTRON MICROSCOPY (3.8 Å) 主引用文献 Structure of the active G i -coupled human lysophosphatidic acid receptor 1 complexed with a potent agonist. Nat Commun, 13, 2022
7YU6	Human Lysophosphatidic Acid Receptor 1-Gi complex bound to ONO-0740556, state2 分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... 著者 Akasaka, H, Shihoya, W, Nureki, O. 登録日 2022-08-16 公開日 2022-10-05 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 Structure of the active G i -coupled human lysophosphatidic acid receptor 1 complexed with a potent agonist. Nat Commun, 13, 2022
7YU8	Human Lysophosphatidic Acid Receptor 1-Gi complex bound to ONO-0740556, state4 分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... 著者 Akasaka, H, Shihoya, W, Nureki, O. 登録日 2022-08-16 公開日 2022-10-05 実験手法 ELECTRON MICROSCOPY (4.5 Å) 主引用文献 Structure of the active G i -coupled human lysophosphatidic acid receptor 1 complexed with a potent agonist. Nat Commun, 13, 2022
6B3J	3.3 angstrom phase-plate cryo-EM structure of a biased agonist-bound human GLP-1 receptor-Gs complex 分子名称: Exendin-P5, Glucagon-like peptide 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Liang, Y.L, Khoshouei, M, Glukhova, A, Furness, S.G.B, Koole, C, Zhao, P, Clydesdale, L, Thal, D.M, Radjainia, M, Danev, R, Baumeister, W, Wang, M.W, Miller, L.J, Christopoulos, A, Sexton, P.M, Wootten, D. 登録日 2017-09-22 公開日 2018-02-21 最終更新日 2020-01-15 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Phase-plate cryo-EM structure of a biased agonist-bound human GLP-1 receptor-Gs complex. Nature, 555, 2018
7O7F	Structural basis of the activation of the CC chemokine receptor 5 by a chemokine agonist 分子名称: C-C chemokine receptor type 5, C-C motif chemokine 5, Fab antibody fragment heavy chain, ... 著者 Isaikina, P, Tsai, C.-J, Dietz, N.B, Pamula, F, Goldie, K.N, Schertler, G.F.X, Maier, T, Stahlberg, H, Deupi, X, Grzesiek, S. 登録日 2021-04-13 公開日 2021-06-30 最終更新日 2022-03-16 実験手法 ELECTRON MICROSCOPY (3.15 Å) 主引用文献 Structural basis of the activation of the CC chemokine receptor 5 by a chemokine agonist. Sci Adv, 7, 2021

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