7NA8

Structures of human ghrelin receptor-Gi complexes with ghrelin and a synthetic agonist

Summary for 7NA8

• Entry DOI: 10.2210/pdb7na8/pdb
• EMDB information: 24268
• Descriptor: Guanine nucleotide-binding protein G(i) subunit alpha-1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (7 entities in total)
• Functional Keywords: gpcr, appetite, energy homeostasis, reward signaling, membrane protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 5
• Total formula weight: 154250.10

Authors

Liu, H.,Sun, D.,Sun, J.,Zhang, C. (deposition date: 2021-06-20, release date: 2021-12-15)

• Primary citation: Liu, H.,Sun, D.,Myasnikov, A.,Damian, M.,Baneres, J.L.,Sun, J.,Zhang, C.; Structural basis of human ghrelin receptor signaling by ghrelin and the synthetic agonist ibutamoren; Nat Commun, 12:6410-, 2021; DOI: 10.1038/s41467-021-26735-5

Experimental method

ELECTRON MICROSCOPY (2.7 Å)