7NA8

Structures of human ghrelin receptor-Gi complexes with ghrelin and a synthetic agonist

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Guanine nucleotide-binding protein G(i) subunit alpha-1	polymer	354	40429.1	1	UniProt (P63096) Pfam (PF00503)	Homo sapiens (Human)	Adenylate cyclase-inhibiting G alpha protein
2	B (B)	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	polymer	340	37417.9	1	UniProt (P62873) Pfam (PF00400)	Homo sapiens (Human)	Transducin beta chain 1
3	C (G)	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	polymer	71	7859.2	1	UniProt (P59768) Pfam (PF00631)	Homo sapiens (Human)	G gamma-I
4	D (N)	Antibody fragment	polymer	246	26236.2	1		Mus musculus (Mouse)
5	E (R)	Growth hormone secretagogue receptor type 1	polymer	366	41392.4	1	UniProt (Q92847) Pfam (PF00001)	Homo sapiens (Human)	GHS-R,GH-releasing peptide receptor,GHRP,Ghrelin receptor
6	F (R)	1-(methanesulfonyl)-1'-(2-methyl-L-alanyl-O-benzyl-D-seryl)-1,2-dihydrospiro[indole-3,4'-piperidine]	non-polymer		528.7	1	Chemie (1KD)
7	G (R)	CHOLESTEROL	non-polymer		386.7	1	Chemie (CLR)

Sequence modifications

A: 1 - 354 (UniProt: P63096)

PDB	External Database	Details
Glu 328	Asp 328	conflict

B: 1 - 340 (UniProt: P62873)

PDB	External Database	Details
Glu 6	Gln 6	conflict
Gln 130	Glu 130	conflict
Asp 237	Asn 237	conflict

G: 1 - 71 (UniProt: P59768)

PDB	External Database	Details
Gln 17	Glu 17	conflict
Gln 58	Glu 58	conflict

R: 1 - 366 (UniProt: Q92847)

PDB	External Database	Details
Lys 130	Thr 130	conflict

Contents of the asymmetric unit

Polymers	Number of chains	5
	Total formula weight	153334.8
Non-Polymers*	Number of molecules	2
	Total formula weight	915.3
All*	Total formula weight	154250.1

*Water molecules are not included.