1TL7

Complex Of Gs- With The Catalytic Domains Of Mammalian Adenylyl Cyclase: Complex With 2'(3')-O-(N-methylanthraniloyl)-guanosine 5'-triphosphate and Mn

Summary for 1TL7

Entry DOI	10.2210/pdb1tl7/pdb
Related	1CJK 1CJT 1CJU 1CJV 1CS4 1CUL
Descriptor	Adenylate cyclase, type V, Adenylate cyclase, type II, Guanine nucleotide-binding protein G(s), alpha subunit, ... (10 entities in total)
Functional Keywords	adenylyl cyclase, gsa, mant-gtp, lyase
Biological source	Canis lupus familiaris (dog) More
Cellular location	Membrane; Multi-pass membrane protein: P30803 P26769 Cell membrane; Lipid-anchor (By similarity): P04896
Total number of polymer chains	3
Total formula weight	96644.54
Authors	Mou, T.C.,Gille, A.,Seifert, R.J.,Sprang, S.R. (deposition date: 2004-06-09, release date: 2004-12-14, Last modification date: 2023-08-23)
Primary citation	Mou, T.C.,Gille, A.,Fancy, D.A.,Seifert, R.,Sprang, S.R. Structural basis for the inhibition of mammalian membrane adenylyl cyclase by 2 '(3')-O-(N-Methylanthraniloyl)-guanosine 5 '-triphosphate. J.Biol.Chem., 280:7253-7261, 2005 Cited by PubMed: 15591060 DOI: 10.1074/jbc.M409076200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation