1TL7
Complex Of Gs- With The Catalytic Domains Of Mammalian Adenylyl Cyclase: Complex With 2'(3')-O-(N-methylanthraniloyl)-guanosine 5'-triphosphate and Mn
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Adenylate cyclase, type V | polymer | 217 | 24495.4 | 1 | UniProt (P30803) Pfam (PF00211) In PDB | Canis lupus familiaris (dog) | ATP pyrophosphate-lyase, Ca2+, -inhibitable adenylyl cyclase |
2 | B | Adenylate cyclase, type II | polymer | 212 | 23717.0 | 1 | UniProt (P26769) Pfam (PF00211) In PDB | Rattus norvegicus (Norway rat) | ATP pyrophosphate-lyase, Adenylyl cyclase |
3 | C | Guanine nucleotide-binding protein G(s), alpha subunit | polymer | 402 | 46656.4 | 1 | UniProt (P04896) Pfam (PF00503) In PDB | Bos taurus (cattle) | Adenylate cyclase-stimulating G alpha protein |
4 | A | MANGANESE (II) ION | non-polymer | 54.9 | 2 | Chemie (MN) | |||
5 | A | FORSKOLIN | non-polymer | 410.5 | 1 | Chemie (FOK) | |||
6 | A | 3'-O-(N-METHYLANTHRANILOYL)-GUANOSINE-5'-TRIPHOSPHATE | non-polymer | 656.3 | 1 | Chemie (ONM) | |||
7 | C | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
8 | C | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
9 | C | 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE | non-polymer | 539.2 | 1 | Chemie (GSP) | |||
10 | water | water | 18.0 | 18 | Chemie (HOH) |
Sequence modifications
A: 364 - 580 (UniProt: P30803)
C: 1 - 394 (UniProt: P04896)
PDB | External Database | Details |
---|---|---|
Met 476 | Val 557 | conflict |
PDB | External Database | Details |
---|---|---|
Gly 71 | 71 | conflict |
- | Gln 79 | deletion |
Asn 79 | Ala 80 | conflict |
Lys 81 | Arg 82 | conflict |
Gly 395 | - | expression tag |
Gly 396 | - | expression tag |
His 397 | - | expression tag |
His 398 | - | expression tag |
His 399 | - | expression tag |
His 400 | - | expression tag |
His 401 | - | expression tag |
His 402 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 3 |
Total formula weight | 94868.8 | |
Non-Polymers* | Number of molecules | 7 |
Total formula weight | 1775.7 | |
All* | Total formula weight | 96644.5 |