1TL7
Complex Of Gs- With The Catalytic Domains Of Mammalian Adenylyl Cyclase: Complex With 2'(3')-O-(N-methylanthraniloyl)-guanosine 5'-triphosphate and Mn
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Adenylate cyclase, type V | polymer | 217 | 24495.4 | 1 | UniProt (P30803) Pfam (PF00211) | Canis lupus familiaris (dog) | ATP pyrophosphate-lyase, Ca2+, -inhibitable adenylyl cyclase |
| 2 | B (B) | Adenylate cyclase, type II | polymer | 212 | 23717.0 | 1 | UniProt (P26769) Pfam (PF00211) | Rattus norvegicus (Norway rat) | ATP pyrophosphate-lyase, Adenylyl cyclase |
| 3 | C (C) | Guanine nucleotide-binding protein G(s), alpha subunit | polymer | 402 | 46656.4 | 1 | UniProt (P04896) Pfam (PF00503) | Bos taurus (cattle) | Adenylate cyclase-stimulating G alpha protein |
| 4 | D, E (A) | MANGANESE (II) ION | non-polymer | 54.9 | 2 | Chemie (MN) PubChem (27854) | |||
| 5 | F (A) | FORSKOLIN | non-polymer | 410.5 | 1 | Chemie (FOK) PubChem (16757823) PubChem (44120009) PubChem (44363887) PubChem (46783813) PubChem (73759682) PubChem (90751269) PubChem (91213948) PubChem (92209816) PubChem (92209817) PubChem (95566308) PubChem (95566309) PubChem (117777632) PubChem (124303810) PubChem (124352399) PubChem (124815399) PubChem (124815400) PubChem (129009935) PubChem (129010250) PubChem (139024465) PubChem (142159939) PubChem (146225314) PubChem (159992414) PubChem (162705519) PubChem (162884402) PubChem (163835172) PubChem (168749335) PubChem (171322913) PubChem (176519959) PubChem (69645774) PubChem (337799) PubChem (486148) PubChem (92209815) PubChem (5702265) PubChem (124404343) PubChem (133612037) PubChem (3413) PubChem (47936) PubChem (6603852) PubChem (6604815) PubChem (6610344) PubChem (9844450) PubChem (13361560) PubChem (13361561) PubChem (13361564) PubChem (13361565) | |||
| 6 | G (A) | 3'-O-(N-METHYLANTHRANILOYL)-GUANOSINE-5'-TRIPHOSPHATE | non-polymer | 656.3 | 1 | Chemie (ONM) PubChem (135509141) PubChem (172874437) | |||
| 7 | H (C) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) PubChem (888) | |||
| 8 | I (C) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) PubChem (312) | |||
| 9 | J (C) | 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE | non-polymer | 539.2 | 1 | Chemie (GSP) PubChem (135398675) PubChem (135476260) PubChem (136073095) PubChem (136440011) PubChem (137176535) PubChem (169450542) | |||
| 10 | K, L, M (A, B, C) | water | water | 18.0 | 18 | Chemie (HOH) |
Sequence modifications
A: 364 - 580 (UniProt: P30803)
C: 1 - 394 (UniProt: P04896)
| PDB | External Database | Details |
|---|---|---|
| Met 476 | Val 557 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Gly 71 | 71 | conflict |
| - | Gln 79 | deletion |
| Asn 79 | Ala 80 | conflict |
| Lys 81 | Arg 82 | conflict |
| Gly 395 | - | expression tag |
| Gly 396 | - | expression tag |
| His 397 | - | expression tag |
| His 398 | - | expression tag |
| His 399 | - | expression tag |
| His 400 | - | expression tag |
| His 401 | - | expression tag |
| His 402 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 94868.8 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 1775.7 | |
| All* | Total formula weight | 96644.5 |
