3EOC
| Cdk2/CyclinA complexed with a imidazo triazin-2-amine | 分子名称: | 5-methyl-7-phenyl-N-(3,4,5-trimethoxyphenyl)imidazo[5,1-f][1,2,4]triazin-2-amine, Cell division protein kinase 2, Cyclin-A2 | 著者 | Cheung, M, Kuntz, K, Pobanz, M, Salovich, J, Wilson, B, Andrews, W, Shewchuk, L, Epperly, A, Hassler, D, Leesnitzer, M, Smith, J, Smith, G, Lansing, T, Mook, R. | 登録日 | 2008-09-26 | 公開日 | 2008-11-04 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Imidazo[5,1-f][1,2,4]triazin-2-amines as novel inhibitors of polo-like kinase 1. Bioorg.Med.Chem.Lett., 18, 2008
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8GXS
| PIC-Mediator in complex with +1 nucleosome (T40N) in H-binding state | 分子名称: | CDK-activating kinase assembly factor MAT1, Cyclin-H, Cyclin-dependent kinase 7, ... | 著者 | Chen, X, Wang, X, Liu, W, Ren, Y, Qu, X, Li, J, Yin, X. | 登録日 | 2022-09-21 | 公開日 | 2022-11-02 | 実験手法 | ELECTRON MICROSCOPY (4.16 Å) | 主引用文献 | Structures of +1 nucleosome-bound PIC-Mediator complex. Science, 378, 2022
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3EID
| CDK2/CyclinA complexed with a pyrazolopyridazine inhibitor | 分子名称: | (2S)-1-(dimethylamino)-3-(4-{[4-(6-morpholin-4-ylpyrazolo[1,5-b]pyridazin-3-yl)pyrimidin-2-yl]amino}phenoxy)propan-2-ol, Cell division protein kinase 2, Cyclin-A2 | 著者 | Steven, K, Reno, M, Alberti, J, Price, D, Kane-Carson, L, Knick, V, Shewchuk, L, Hassell, A, Veal, J, Peel, M. | 登録日 | 2008-09-15 | 公開日 | 2008-10-21 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (3.15 Å) | 主引用文献 | Synthesis and evaluation of pyrazolo[1,5-b]pyridazines as selective cyclin dependent kinase inhibitors. Bioorg.Med.Chem.Lett., 18, 2008
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8GXQ
| PIC-Mediator in complex with +1 nucleosome (T40N) in MH-binding state | 分子名称: | CDK-activating kinase assembly factor MAT1, Cyclin-H, Cyclin-dependent kinase 7, ... | 著者 | Chen, X, Wang, X, Liu, W, Ren, Y, Qu, X, Li, J, Yin, X, Xu, Y. | 登録日 | 2022-09-21 | 公開日 | 2022-11-02 | 実験手法 | ELECTRON MICROSCOPY (5.04 Å) | 主引用文献 | Structures of +1 nucleosome-bound PIC-Mediator complex. Science, 378, 2022
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8H6P
| Complex structure of CDK2/Cyclin E1 and a potent, selective macrocyclic inhibitor | 分子名称: | (7S,10R)-11-oxa-2,4,5,13,17,23-hexaazatetracyclo[17.3.1.1~3,6~.1~7,10~]pentacosa-1(23),3(25),5,19,21-pentaene-12,18-dione, Cyclin-dependent kinase 2, G1/S-specific cyclin-E1 | 著者 | Ren, X. | 登録日 | 2022-10-18 | 公開日 | 2023-02-22 | 最終更新日 | 2023-03-29 | 実験手法 | X-RAY DIFFRACTION (2.44 Å) | 主引用文献 | Accelerated Discovery of Macrocyclic CDK2 Inhibitor QR-6401 by Generative Models and Structure-Based Drug Design. Acs Med.Chem.Lett., 14, 2023
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8H6T
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8H4R
| The Crystal Structure of CDK3 and CyclinE1 Complex with Dinaciclib from Biortus | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 3-[({3-ethyl-5-[(2S)-2-(2-hydroxyethyl)piperidin-1-yl]pyrazolo[1,5-a]pyrimidin-7-yl}amino)methyl]-1-hydroxypyridinium, G1/S-specific cyclin-E1, ... | 著者 | Gui, W, Wang, F, Cheng, W, Gao, J, Huang, Y, Ouyang, Z. | 登録日 | 2022-10-11 | 公開日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | 主引用文献 | The Crystal Structure of CDK3 and CyclinE1 Complex with Dinaciclib from Biortus To Be Published
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3F5X
| CDK-2-Cyclin complex with indazole inhibitor 9 bound at its active site | 分子名称: | 4-{3-[7-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-indazol-6-yl}aniline, Cell division protein kinase 2, Cyclin-A2, ... | 著者 | Kiefer, J.R, Day, J.E, Caspers, N.L, Mathis, K.J, Kretzmer, K.K, Weinberg, R.A, Reitz, B.A, Stegeman, R.A, Trujillo, J.I, Huang, W, Thorarensen, A, Xing, L, Wrightstone, A, Christine, L, Compton, R, Li, X. | 登録日 | 2008-11-04 | 公開日 | 2009-02-03 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | 2-(6-Phenyl-1H-indazol-3-yl)-1H-benzo[d]imidazoles: Design and synthesis of a potent and isoform selective PKC-zeta inhibitor. Bioorg.Med.Chem.Lett., 19, 2009
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3G33
| Crystal structure of CDK4/cyclin D3 | 分子名称: | CCND3 protein, Cell division protein kinase 4 | 著者 | Takaki, T, Echalier, A, Brown, N.R, Hunt, T, Endicott, J.A, Noble, M.E.M. | 登録日 | 2009-02-01 | 公開日 | 2009-03-10 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | The structure of CDK4/cyclin D3 has implications for models of CDK activation. Proc.Natl.Acad.Sci.USA, 106, 2009
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8I0L
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3QHR
| Structure of a pCDK2/CyclinA transition-state mimic | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, CDK2 substrate peptide: PKTPKKAKKL, CHLORIDE ION, ... | 著者 | Young, M.A, Jacobsen, D.M, Bao, Z.Q. | 登録日 | 2011-01-26 | 公開日 | 2011-05-25 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.17 Å) | 主引用文献 | Briefly Bound to Activate: Transient Binding of a Second Catalytic Magnesium Activates the Structure and Dynamics of CDK2 Kinase for Catalysis. Structure, 19, 2011
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3QHW
| Structure of a pCDK2/CyclinA transition-state mimic | 分子名称: | (2R,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL, ADENOSINE-5'-DIPHOSPHATE, CDK2 substrate peptide: PKTPKKAKKL, ... | 著者 | Young, M.A, Jacobsen, D.M, Bao, Z.Q. | 登録日 | 2011-01-26 | 公開日 | 2011-05-25 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.91 Å) | 主引用文献 | Briefly Bound to Activate: Transient Binding of a Second Catalytic Magnesium Activates the Structure and Dynamics of CDK2 Kinase for Catalysis. Structure, 19, 2011
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3RGF
| Crystal Structure of human CDK8/CycC | 分子名称: | 1,2-ETHANEDIOL, 4-{4-[({[4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL]AMINO}CARBONYL)AMINO]PHENOXY}-N-METHYLPYRIDINE-2-CARBOXAMIDE, Cyclin-C, ... | 著者 | Schneider, E.V, Boettcher, J, Blaesse, M, Huber, R, Maskos, K. | 登録日 | 2011-04-08 | 公開日 | 2011-08-10 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | The Structure of CDK8/CycC Implicates Specificity in the CDK/Cyclin Family and Reveals Interaction with a Deep Pocket Binder. J.Mol.Biol., 412, 2011
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3TN8
| CDK9/cyclin T in complex with CAN508 | 分子名称: | 4-[(E)-(3,5-DIAMINO-1H-PYRAZOL-4-YL)DIAZENYL]PHENOL, Cyclin-T1, Cyclin-dependent kinase 9, ... | 著者 | Baumli, S, Hole, A.J, Endicott, J.E. | 登録日 | 2011-09-01 | 公開日 | 2012-02-15 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.95 Å) | 主引用文献 | The CDK9 C-helix Exhibits Conformational Plasticity That May Explain the Selectivity of CAN508. Acs Chem.Biol., 7, 2012
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3TNW
| Structure of CDK2/cyclin A in complex with CAN508 | 分子名称: | 4-[(E)-(3,5-DIAMINO-1H-PYRAZOL-4-YL)DIAZENYL]PHENOL, Cyclin-A2, Cyclin-dependent kinase 2, ... | 著者 | Baumli, S, Hole, A.J, Endicott, J.A. | 登録日 | 2011-09-02 | 公開日 | 2012-02-15 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | The CDK9 C-helix Exhibits Conformational Plasticity That May Explain the Selectivity of CAN508. Acs Chem.Biol., 7, 2012
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3TNI
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3TNH
| CDK9/cyclin T in complex with CAN508 | 分子名称: | 4-[(E)-(3,5-DIAMINO-1H-PYRAZOL-4-YL)DIAZENYL]PHENOL, Cyclin-T1, Cyclin-dependent kinase 9 | 著者 | Baumli, S, Hole, A.J, Endicott, J.A. | 登録日 | 2011-09-01 | 公開日 | 2012-02-15 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (3.202 Å) | 主引用文献 | The CDK9 C-helix Exhibits Conformational Plasticity That May Explain the Selectivity of CAN508. Acs Chem.Biol., 7, 2012
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6Y0A
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6Z45
| CDK9-Cyclin-T1 complex bound by compound 24 | 分子名称: | (1~{S},3~{R})-3-acetamido-~{N}-[5-chloranyl-4-(5,5-dimethyl-4,6-dihydropyrrolo[1,2-b]pyrazol-3-yl)pyridin-2-yl]cyclohexane-1-carboxamide, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Cyclin-T1, ... | 著者 | Ferguson, A, Collie, G.W. | 登録日 | 2020-05-22 | 公開日 | 2020-12-23 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (3.37 Å) | 主引用文献 | Discovery of AZD4573, a Potent and Selective Inhibitor of CDK9 That Enables Short Duration of Target Engagement for the Treatment of Hematological Malignancies. J.Med.Chem., 63, 2020
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7JV7
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7KPV
| Structure of kinase and Central lobes of yeast CKM | 分子名称: | Mediator of RNA polymerase II transcription subunit 12, Mediator of RNA polymerase II transcription subunit 13, Meiotic mRNA stability protein kinase SSN3, ... | 著者 | Li, Y.C, Chao, T.C, Kim, H.J, Cholko, T, Chen, S.F, Nakanishi, K, Chang, C.E, Murakami, K, Garcia, B.A, Boyer, T.G, Tsai, K.L. | 登録日 | 2020-11-12 | 公開日 | 2021-01-27 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Structure and noncanonical Cdk8 activation mechanism within an Argonaute-containing Mediator kinase module. Sci Adv, 7, 2021
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7KPX
| Structure of the yeast CKM | 分子名称: | Mediator of RNA polymerase II transcription subunit 12, Mediator of RNA polymerase II transcription subunit 13, Meiotic mRNA stability protein kinase SSN3, ... | 著者 | Li, Y.C, Chao, T.C, Kim, H.J, Cholko, T, Chen, S.F, Nakanishi, K, Chang, C.E, Murakami, K, Garcia, B.A, Boyer, T.G, Tsai, K.L. | 登録日 | 2020-11-12 | 公開日 | 2021-01-27 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (4.4 Å) | 主引用文献 | Structure and noncanonical Cdk8 activation mechanism within an Argonaute-containing Mediator kinase module. Sci Adv, 7, 2021
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7LBM
| Structure of the human Mediator-bound transcription pre-initiation complex | 分子名称: | CDK-activating kinase assembly factor MAT1, Cyclin-H, Cyclin-dependent kinase 7, ... | 著者 | Abdella, R, Talyzina, A, He, Y. | 登録日 | 2021-01-08 | 公開日 | 2021-03-24 | 最終更新日 | 2021-04-14 | 実験手法 | ELECTRON MICROSCOPY (4.8 Å) | 主引用文献 | Structure of the human Mediator-bound transcription preinitiation complex. Science, 372, 2021
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7KUE
| CryoEM structure of Yeast TFIIK (Kin28/Ccl1/Tfb3) Complex | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, Cyclin CCL1, ... | 著者 | van Eeuwen, T, Murakami, K, Li, T, Tsai, K.L. | 登録日 | 2020-11-24 | 公開日 | 2021-04-28 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Structure of TFIIK for phosphorylation of CTD of RNA polymerase II. Sci Adv, 7, 2021
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7KJS
| Crystal structure of CDK2/cyclin E in complex with PF-06873600 | 分子名称: | 6-(difluoromethyl)-8-[(1R,2R)-2-hydroxy-2-methylcyclopentyl]-2-{[1-(methylsulfonyl)piperidin-4-yl]amino}pyrido[2,3-d]pyrimidin-7(8H)-one, Cyclin-dependent kinase 2, G1/S-specific cyclin-E1 | 著者 | McTigue, M.A, He, Y, Ferre, R.A. | 登録日 | 2020-10-26 | 公開日 | 2021-06-23 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.187 Å) | 主引用文献 | Discovery of PF-06873600, a CDK2/4/6 Inhibitor for the Treatment of Cancer. J.Med.Chem., 64, 2021
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