3EOC

Cdk2/CyclinA complexed with a imidazo triazin-2-amine

Summary for 3EOC

• Entry DOI: 10.2210/pdb3eoc/pdb
• Descriptor: Cell division protein kinase 2, Cyclin-A2, 5-methyl-7-phenyl-N-(3,4,5-trimethoxyphenyl)imidazo[5,1-f][1,2,4]triazin-2-amine (3 entities in total)
• Functional Keywords: cdk, cyclin, atp-binding, cell cycle, cell division, kinase, mitosis, nucleotide-binding, phosphoprotein, serine/threonine-protein kinase, transferase, nucleus, transferase-cell cycle complex, transferase/cell cycle
• Biological source: Homo sapiens; More
• Total number of polymer chains: 4
• Total formula weight: 128470.85

Authors

Cheung, M.,Kuntz, K.,Pobanz, M.,Salovich, J.,Wilson, B.,Andrews, W.,Shewchuk, L.,Epperly, A.,Hassler, D.,Leesnitzer, M.,Smith, J.,Smith, G.,Lansing, T.,Mook, R. (deposition date: 2008-09-26, release date: 2008-11-04, Last modification date: 2023-09-06)

Primary citation

Cheung, M.,Kuntz, K.W.,Pobanz, M.,Salovich, J.M.,Wilson, B.J.,Andrews, C.W.,Shewchuk, L.M.,Epperly, A.H.,Hassler, D.F.,Leesnitzer, M.A.,Smith, J.L.,Smith, G.K.,Lansing, T.J.,Mook, R.A.
Imidazo[5,1-f][1,2,4]triazin-2-amines as novel inhibitors of polo-like kinase 1.
Bioorg.Med.Chem.Lett., 18:6214-6217, 2008

PubMed Abstract: The synthesis and biological activities of imidazo[5,1-f][1,2,4]triazin-2-amines (imidazotriazines) as novel polo-like kinase 1 inhibitors are reported.

PubMed: 18929484
DOI: 10.1016/j.bmcl.2008.09.100

Experimental method

X-RAY DIFFRACTION (3.2 Å)