PDB: 435 件ウェブページステータス検索Chemie searchBIRD

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4GBL	Crystal structure of aspart insulin at pH 8.5 分子名称: CHLORIDE ION, Insulin A chain, Insulin B chain, ... 著者 Lima, L.M.T.R, Favero-Retto, M.P, Palmieri, L.C. 登録日 2012-07-27 公開日 2013-06-12 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 A T3R3 hexamer of the human insulin variant B28Asp. Biophys.Chem., 173, 2013
2M2P	Structure of [D-HisB24] insulin analogue at pH 8.0 分子名称: Insulin A chain, Insulin B chain 著者 Zakova, L, Veverka, V, Jiracek, J. 登録日 2012-12-29 公開日 2013-03-06 最終更新日 2013-06-05 実験手法 SOLUTION NMR 主引用文献 Structural integrity of the B24 site in human insulin is important for hormone functionality. J.Biol.Chem., 288, 2013
2M2M	Structure of [L-HisB24] insulin analogue at pH 1.9 分子名称: Insulin A chain, Insulin B chain 著者 Zakova, L, Veverka, V, Jiracek, J. 登録日 2012-12-28 公開日 2013-03-06 最終更新日 2013-06-05 実験手法 SOLUTION NMR 主引用文献 Structural integrity of the B24 site in human insulin is important for hormone functionality. J.Biol.Chem., 288, 2013
2MVD	Solution structure of [GlnB22]-insulin mutant at pH 1.9 分子名称: Insulin A chain, Insulin B chain 著者 Hexnerova, R, Krizkova, K, Maletinska, L, Jiracek, J, Brzozowski, A.M, Zakova, L, Veverka, V. 登録日 2014-10-02 公開日 2014-12-10 最終更新日 2023-06-14 実験手法 SOLUTION NMR 主引用文献 Structural and Functional Study of the GlnB22-Insulin Mutant Responsible for Maturity-Onset Diabetes of the Young. Plos One, 9, 2014
2N2X	Solution structure of [GlyB24,B27-B29 triazole cross-linked]-insulin analogue at pH 1.9 分子名称: Insulin A chain, Insulin B chain 著者 Veverka, V, Hexnerova, R, Jiracek, J. 登録日 2015-05-15 公開日 2016-02-03 最終更新日 2023-12-27 実験手法 SOLUTION NMR 主引用文献 Rational steering of insulin binding specificity by intra-chain chemical crosslinking. Sci Rep, 6, 2016
2MPI	Solution structure of B24G insulin 分子名称: insulin chain A, insulin chain B 著者 Yang, Y, Wickramasinghe, N.P, Hua, Q, Weiss, M.A. 登録日 2014-05-19 公開日 2014-12-24 最終更新日 2023-06-14 実験手法 SOLUTION NMR 主引用文献 Protective hinge in insulin opens to enable its receptor engagement. Proc.Natl.Acad.Sci.USA, 111, 2014
2N2W	Solution structure of [B26-B29 triazole cross-linked]-insulin analogue at pH 8.0 分子名称: Insulin A chain, Insulin B chain 著者 Veverka, V, Hexnerova, R, Jiracek, J. 登録日 2015-05-15 公開日 2016-02-03 実験手法 SOLUTION NMR 主引用文献 Rational steering of insulin binding specificity by intra-chain chemical crosslinking. Sci Rep, 6, 2016
2MPG	Solution structure of the [AibB8,LysB28,ProB29]-insulin analogue 分子名称: Insulin A chain, Insulin B chain 著者 Kosinova, L, Jiracek, J, Zakova, L, Veverka, V. 登録日 2014-05-17 公開日 2014-06-11 最終更新日 2023-12-27 実験手法 SOLUTION NMR 主引用文献 Insight into the structural and biological relevance of the T/R transition of the N-terminus of the B-chain in human insulin. Biochemistry, 53, 2014
2N2V	Solution structure of [B26-B29 triazole cross-linked]-insulin analogue at pH 1.9 分子名称: Insulin A chain, Insulin B chain 著者 Veverka, V, Hexnerova, R, Jiracek, J. 登録日 2015-05-15 公開日 2016-02-03 実験手法 SOLUTION NMR 主引用文献 Rational steering of insulin binding specificity by intra-chain chemical crosslinking. Sci Rep, 6, 2016
2MVC	Solution structure of human insulin at pH 1.9 分子名称: Insulin A chain, Insulin B chain 著者 Hexnerova, R, Krizkova, K, Maletinska, L, Jiracek, J, Brzozowski, A.M, Zakova, L, Veverka, V. 登録日 2014-10-02 公開日 2014-12-10 最終更新日 2016-06-01 実験手法 SOLUTION NMR 主引用文献 Structural and Functional Study of the GlnB22-Insulin Mutant Responsible for Maturity-Onset Diabetes of the Young. Plos One, 9, 2014
2OMG	Structure of human insulin cocrystallized with protamine and urea 分子名称: CHLORIDE ION, FORMAMIDE, Insulin A chain, ... 著者 Norrman, M, Schluckebier, G. 登録日 2007-01-22 公開日 2007-03-27 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.52 Å) 主引用文献 Structural characterization of insulin NPH formulations. EUR.J.PHARM.SCI., 30, 2007
2OLZ	Structure of human insulin in presence of thiocyanate at pH 7.0 分子名称: GLYCEROL, Insulin A, Insulin B, ... 著者 Norrman, M, Schluckebier, G. 登録日 2007-01-20 公開日 2007-12-04 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Crystallographic characterization of two novel crystal forms of human insulin induced by chaotropic agents and a shift in pH. Bmc Struct.Biol., 7, 2007
8CLS	Drosophila melanogaster insulin receptor ectodomain in complex with DILP5 分子名称: Insulin-like receptor, Probable insulin-like peptide 5, Probable insulin-like peptide 5 A chain 著者 Viola, C.M, Brzozowski, A.M, Shafi, T. 登録日 2023-02-17 公開日 2023-12-20 実験手法 ELECTRON MICROSCOPY (4 Å) 主引用文献 Structural conservation of insulin/IGF signalling axis at the insulin receptors level in Drosophila and humans. Nat Commun, 14, 2023
4XSS	Insulin-like growth factor I in complex with site 1 of a hybrid insulin receptor / Type 1 insulin-like growth factor receptor 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin receptor, ... 著者 Lawrence, C, Kong, G.K.-W, Menting, J.G, Lawrence, M.C. 登録日 2015-01-22 公開日 2015-06-10 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Structural Congruency of Ligand Binding to the Insulin and Insulin/Type 1 Insulin-like Growth Factor Hybrid Receptors. Structure, 23, 2015
7KD6	Insulin Receptor L1-CR plus alphaCT fragment in co-complex with Fv 83-7 and single-chain insulin SCI-b 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Lawrence, M.C, Menting, J.G. 登録日 2020-10-08 公開日 2021-10-13 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Single-chain insulin analogs threaded by the insulin receptor alpha CT domain. Biophys.J., 2022
4OGA	Insulin in complex with Site 1 of the human insulin receptor 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin A chain, Insulin B chain, ... 著者 Lawrence, M.C, Menting, J.G. 登録日 2014-01-15 公開日 2014-08-27 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (3.5 Å) 主引用文献 Protective hinge in insulin opens to enable its receptor engagement. Proc.Natl.Acad.Sci.USA, 111, 2014
6B70	Cryo-EM structure of human insulin degrading enzyme in complex with FAB H11-E heavy chain, FAB H11-E light chain and insulin 分子名称: FAB H11-E heavy chain, FAB H11-E light chain, Insulin, ... 著者 Liang, W.G, Zhang, Z, Bailey, L.J, Kossiakoff, A.A, Tan, Y.Z, Wei, H, Carragher, B, Potter, S.C, Tang, W.J. 登録日 2017-10-03 公開日 2017-12-27 最終更新日 2021-04-28 実験手法 ELECTRON MICROSCOPY (3.7 Å) 主引用文献 Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme. Elife, 7, 2018
6BFC	Cryo-EM structure of human insulin degrading enzyme in complex with insulin 分子名称: Insulin, Insulin-degrading enzyme 著者 Liang, W.G, Zhang, Z, Bailey, L.J, Kossiakoff, A.A, Tan, Y.Z, Wei, H, Carragher, B, Potter, S.C, Tang, W.J. 登録日 2017-10-26 公開日 2017-12-27 最終更新日 2021-04-28 実験手法 ELECTRON MICROSCOPY (3.7 Å) 主引用文献 Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme. Elife, 7, 2018
6B3Q	Cryo-EM structure of human insulin degrading enzyme in complex with insulin 分子名称: Insulin, Insulin-degrading enzyme 著者 Liang, W.G, Zhang, Z, Bailey, L.J, Kossiakoff, A.A, Tan, Y.Z, Wei, H, Carragher, B, Potter, S.C, Tang, W.J. 登録日 2017-09-22 公開日 2017-11-22 最終更新日 2021-04-28 実験手法 ELECTRON MICROSCOPY (3.7 Å) 主引用文献 Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme. Elife, 7, 2018
7WRQ	Structure of Human IGF1/IGFBP3/ALS Ternary Complex 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin-like growth factor-binding protein 3, Insulin-like growth factor-binding protein complex acid labile subunit, ... 著者 Kim, H, Fu, Y, Kim, H.M. 登録日 2022-01-27 公開日 2022-08-10 実験手法 ELECTRON MICROSCOPY (3.6 Å) 主引用文献 Structural basis for assembly and disassembly of the IGF/IGFBP/ALS ternary complex Nat Commun, 13, 2022
6FF3	Crystal structure of Drosophila neural ectodermal development factor Imp-L1 with Human IGF-I 分子名称: Insulin-like growth factor I, Neural/ectodermal development factor IMP-L2 著者 Brzozowski, A.M, Kulahin, N, Kristensen, O, Schluckebier, G, Meyts, P.D, Viola, C.M. 登録日 2018-01-03 公開日 2018-09-26 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.57 Å) 主引用文献 Structures of insect Imp-L2 suggest an alternative strategy for regulating the bioavailability of insulin-like hormones. Nat Commun, 9, 2018
6FEY	Crystal structure of Drosophila neural ectodermal development factor Imp-L2 with Drosophila DILP5 insulin 分子名称: Neural/ectodermal development factor IMP-L2, Probable insulin-like peptide 5 著者 Brzozowski, A.M, Kulahin, N, Kristensen, O, Schluckebier, G, Meyts, P.D. 登録日 2018-01-03 公開日 2018-09-26 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (3.48 Å) 主引用文献 Structures of insect Imp-L2 suggest an alternative strategy for regulating the bioavailability of insulin-like hormones. Nat Commun, 9, 2018
6VEP	Human insulin in complex with the human insulin microreceptor in turn in complex with Fv 83-7 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Lawrence, M.C, Menting, J.G.T. 登録日 2020-01-02 公開日 2020-06-03 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 A structurally minimized yet fully active insulin based on cone-snail venom insulin principles. Nat.Struct.Mol.Biol., 27, 2020
3E4Z	Crystal structure of human insulin degrading enzyme in complex with insulin-like growth factor II 分子名称: Insulin-degrading enzyme, Insulin-like growth factor II, ZINC ION 著者 Guo, Q, Manolopoulou, M, Tang, W.-J. 登録日 2008-08-12 公開日 2009-08-18 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.28 Å) 主引用文献 Molecular Basis for the Recognition and Cleavages of IGF-II, TGF-alpha, and Amylin by Human Insulin-Degrading Enzyme. J.Mol.Biol., 395, 2010
5KQV	Insulin receptor ectodomain construct comprising domains L1,CR,L2, FnIII-1 and alphaCT peptide in complex with bovine insulin and FAB 83-14 (REVISED STRUCTURE) 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin, Insulin receptor,Insulin receptor, ... 著者 Lawrence, M.C, Smith, B.J, Croll, T.I. 登録日 2016-07-06 公開日 2017-07-19 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (4.4 Å) 主引用文献 How insulin engages its primary binding site on the insulin receptor. Nature, 493, 2013

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