Solution structure of human insulin at pH 1.9

Summary for 2MVC

Related2HIU 2MVD
DescriptorInsulin A chain, Insulin B chain (2 entities in total)
Functional Keywordsinsulin, hormone
Biological sourceHomo sapiens (Human)
Cellular locationSecreted P01308 P01308
Total number of polymer chains2
Total molecular weight5817.65
Hexnerova, R.,Krizkova, K.,Maletinska, L.,Jiracek, J.,Brzozowski, A.M.,Zakova, L.,Veverka, V. (deposition date: 2014-10-02, release date: 2014-12-10, Last modification date: 2016-06-01)
Primary citation
Krizkova, K.,Veverka, V.,Maletinska, L.,Hexnerova, R.,Brzozowski, A.M.,Jiracek, J.,Zakova, L.
Structural and Functional Study of the GlnB22-Insulin Mutant Responsible for Maturity-Onset Diabetes of the Young.
Plos One, 9:e112883-e112883, 2014
PubMed: 25423173 (PDB entries with the same primary citation)
DOI: 10.1371/journal.pone.0112883
MImport into Mendeley
Experimental method
NMR Information

Structure validation

ClashscoreRamachandran outliersSidechain outliers00.1%5.0%MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all NMR structures
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