2N2V

Solution structure of [B26-B29 triazole cross-linked]-insulin analogue at pH 1.9

Summary for 2N2V

Related2N2w 2N2X
DescriptorInsulin A chain, Insulin B chain (2 entities in total)
Functional Keywordshormone
Biological sourceHomo sapiens (human)
Cellular locationSecreted P01308 P01308
Total number of polymer chains2
Total molecular weight5762.56
Authors
Veverka, V.,Hexnerova, R.,Jiracek, J. (deposition date: 2015-05-15, release date: 2016-02-03)
Primary citation
Vikova, J.,Collinsova, M.,Kletvikova, E.,Budesinsky, M.,Kaplan, V.,Zakova, L.,Veverka, V.,Hexnerova, R.,Avino, R.J.,Strakova, J.,Selicharova, I.,Vanek, V.,Wright, D.W.,Watson, C.J.,Turkenburg, J.P.,Brzozowski, A.M.,Jiracek, J.
Rational steering of insulin binding specificity by intra-chain chemical crosslinking.
Sci Rep, 6:19431-19431, 2016
PubMed: 26792393 (PDB entries with the same primary citation)
DOI: 10.1038/srep19431
MImport into Mendeley
Experimental method
SOLUTION NMR
NMR Information
?

Structure validation

ClashscoreRamachandran outliersSidechain outliers00.1%12.6%MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all NMR structures