4NN6
 
 | | Cytokine receptor complex - Crystal form 1B | | Descriptor: | Cytokine receptor-like factor 2, Interleukin-7 receptor subunit alpha, Thymic stromal lymphopoietin | | Authors: | Verstraete, K, van Schie, L, Savvides, S.N. | | Deposit date: | 2013-11-16 | | Release date: | 2014-03-19 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (2.545 Å) | | Cite: | Structural basis of the proinflammatory signaling complex mediated by TSLP.
Nat.Struct.Mol.Biol., 21, 2014
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4NN5
 | | Cytokine receptor complex - Crystal form 1A | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, Cytokine receptor-like factor 2, ... | | Authors: | Verstraete, K, van Schie, L, Savvides, S.N. | | Deposit date: | 2013-11-16 | | Release date: | 2014-03-19 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (1.898 Å) | | Cite: | Structural basis of the proinflammatory signaling complex mediated by TSLP.
Nat.Struct.Mol.Biol., 21, 2014
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4NN7
 | | Cytokine receptor complex - Crystal form 2 | | Descriptor: | Cytokine receptor-like factor 2, Interleukin-7 receptor subunit alpha, Thymic stromal lymphopoietin | | Authors: | Verstraete, K, van Schie, L, Savvides, S.N. | | Deposit date: | 2013-11-16 | | Release date: | 2014-03-19 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (3.775 Å) | | Cite: | Structural basis of the proinflammatory signaling complex mediated by TSLP.
Nat.Struct.Mol.Biol., 21, 2014
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7Z0L
 | | IL-27 signalling complex | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-27 receptor subunit alpha, ... | | Authors: | Jin, Y, Gardner, S, Bubeck, D. | | Deposit date: | 2022-02-23 | | Release date: | 2022-07-27 | | Last modified: | 2022-10-19 | | Method: | ELECTRON MICROSCOPY (4 Å) | | Cite: | Structural insights into the assembly and activation of the IL-27 signaling complex.
Embo Rep., 23, 2022
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7YQ6
 | | human insulin receptor bound with A62 DNA aptamer | | Descriptor: | IR-A62 aptamer, Isoform Short of Insulin receptor | | Authors: | Kim, J, Yunn, N, Ryu, S, Cho, Y. | | Deposit date: | 2022-08-05 | | Release date: | 2022-11-09 | | Last modified: | 2024-05-08 | | Method: | ELECTRON MICROSCOPY (4.18 Å) | | Cite: | Functional selectivity of insulin receptor revealed by aptamer-trapped receptor structures.
Nat Commun, 13, 2022
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7YQ4
 | | human insulin receptor bound with A62 DNA aptamer and insulin - locally refined | | Descriptor: | IR-A62 aptamer, Insulin A chain, Insulin, ... | | Authors: | Kim, J, Yunn, N, Ryu, S, Cho, Y. | | Deposit date: | 2022-08-05 | | Release date: | 2022-11-09 | | Last modified: | 2024-05-08 | | Method: | ELECTRON MICROSCOPY (3.95 Å) | | Cite: | Functional selectivity of insulin receptor revealed by aptamer-trapped receptor structures.
Nat Commun, 13, 2022
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7YQ3
 | | human insulin receptor bound with A43 DNA aptamer and insulin | | Descriptor: | IR-A43 aptamer, Insulin A chain, Insulin, ... | | Authors: | Kim, J, Yunn, N, Ryu, S, Cho, Y. | | Deposit date: | 2022-08-05 | | Release date: | 2022-11-09 | | Last modified: | 2024-05-08 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | Functional selectivity of insulin receptor revealed by aptamer-trapped receptor structures.
Nat Commun, 13, 2022
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7YQ5
 | | human insulin receptor bound with A62 DNA aptamer and insulin | | Descriptor: | IR-A62 aptamer, Insulin A chain, Insulin, ... | | Authors: | Kim, J, Yunn, N, Ryu, S, Cho, Y. | | Deposit date: | 2022-08-05 | | Release date: | 2022-11-09 | | Last modified: | 2024-05-08 | | Method: | ELECTRON MICROSCOPY (4.27 Å) | | Cite: | Functional selectivity of insulin receptor revealed by aptamer-trapped receptor structures.
Nat Commun, 13, 2022
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7YRR
 | | Cryo-EM structure of IGF1R with two IGF1 complex | | Descriptor: | Insulin-like growth factor 1 receptor, Isoform 3 of Insulin-like growth factor I | | Authors: | Xi, Z, Cang, W. | | Deposit date: | 2022-08-10 | | Release date: | 2023-08-16 | | Method: | ELECTRON MICROSCOPY (4.3 Å) | | Cite: | Cryo-EM structure of IGF1R with two IGF1 complex at 4.3 angstroms resolution
To Be Published
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8D7H
 | | Cryo-EM structure of human CLCF1 in complex with CRLF1 and CNTFR alpha | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Cardiotrophin-like cytokine factor 1, ... | | Authors: | Zhou, Y, Franklin, M.C. | | Deposit date: | 2022-06-07 | | Release date: | 2023-03-29 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Structural insights into the assembly of gp130 family cytokine signaling complexes.
Sci Adv, 9, 2023
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8D82
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8D74
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8D7R
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8D6A
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8D85
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8A1F
 | | Human PTPRK N-terminal domains MAM-Ig-FN1 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Hay, I.M, Graham, S.C, Sharpe, H.J, Deane, J.E. | | Deposit date: | 2022-06-01 | | Release date: | 2023-03-15 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Determinants of receptor tyrosine phosphatase homophilic adhesion: Structural comparison of PTPRK and PTPRM extracellular domains.
J.Biol.Chem., 299, 2023
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8DPT
 | | The structure of the IL-11 signalling complex, with full-length extracellular gp130 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-11, ... | | Authors: | Metcalfe, R.D, Hanssen, E, Griffin, M.D.W. | | Deposit date: | 2022-07-17 | | Release date: | 2023-11-29 | | Last modified: | 2024-05-01 | | Method: | ELECTRON MICROSCOPY (4 Å) | | Cite: | Structures of the interleukin 11 signalling complex reveal gp130 dynamics and the inhibitory mechanism of a cytokine variant.
Nat Commun, 14, 2023
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8DPS
 | | The structure of the interleukin 11 signalling complex, truncated gp130 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-11, ... | | Authors: | Metcalfe, R.D, Hanssen, E, Griffin, M.D.W. | | Deposit date: | 2022-07-17 | | Release date: | 2023-11-29 | | Last modified: | 2024-05-01 | | Method: | ELECTRON MICROSCOPY (3.47 Å) | | Cite: | Structures of the interleukin 11 signalling complex reveal gp130 dynamics and the inhibitory mechanism of a cytokine variant.
Nat Commun, 14, 2023
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8DPU
 | | The crystal structure of the IL-11 signalling complex | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-11, ... | | Authors: | Metcalfe, R.D, Aizel, K, Griffin, M.D.W. | | Deposit date: | 2022-07-17 | | Release date: | 2023-11-29 | | Last modified: | 2024-05-01 | | Method: | X-RAY DIFFRACTION (3.78 Å) | | Cite: | Structures of the interleukin 11 signalling complex reveal gp130 dynamics and the inhibitory mechanism of a cytokine variant.
Nat Commun, 14, 2023
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8DTM
 | | Cryo-EM structure of insulin receptor (IR) bound with S597 component 2 | | Descriptor: | Insulin mimetic peptide S597 component 2, Insulin receptor | | Authors: | Park, J, Li, J, Mayer, J.P, Ball, K.A, Wu, J.Y, Hall, C, Accili, D, Stowell, M.H.B, Bai, X.C, Choi, E. | | Deposit date: | 2022-07-26 | | Release date: | 2022-09-07 | | Last modified: | 2022-10-12 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | Activation of the insulin receptor by an insulin mimetic peptide.
Nat Commun, 13, 2022
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8DTL
 | | Cryo-EM structure of insulin receptor (IR) bound with S597 peptide | | Descriptor: | Insulin mimetic peptide S597, Insulin receptor | | Authors: | Park, J, Li, J, Mayer, J.P, Ball, K.A, Wu, J.Y, Hall, C, Accili, D, Stowell, M.H.B, Bai, X.C, Choi, E. | | Deposit date: | 2022-07-25 | | Release date: | 2022-09-07 | | Last modified: | 2022-10-12 | | Method: | ELECTRON MICROSCOPY (5.4 Å) | | Cite: | Activation of the insulin receptor by an insulin mimetic peptide.
Nat Commun, 13, 2022
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8EYY
 | | Cryo-EM structure of 4 insulins bound full-length mouse IR mutant with physically decoupled alpha CTs (C684S/C685S/C687S, denoted as IR-3CS) Asymmetric conformation 2 | | Descriptor: | Insulin, Insulin receptor | | Authors: | Li, J, Wu, J.Y, Hall, C, Bai, X.C, Choi, E. | | Deposit date: | 2022-10-29 | | Release date: | 2022-11-09 | | Last modified: | 2022-12-07 | | Method: | ELECTRON MICROSCOPY (4.9 Å) | | Cite: | Molecular basis for the role of disulfide-linked alpha CTs in the activation of insulin-like growth factor 1 receptor and insulin receptor.
Elife, 11, 2022
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8EZ0
 | | Cryo-EM structure of 4 insulins bound full-length mouse IR mutant with physically decoupled alpha CTs (C684S/C685S/C687S; denoted as IR-3CS) Symmetric conformation | | Descriptor: | Insulin, Insulin receptor | | Authors: | Li, J, Wu, J.Y, Hall, C, Bai, X.C, Choi, E. | | Deposit date: | 2022-10-29 | | Release date: | 2022-11-09 | | Last modified: | 2023-08-30 | | Method: | ELECTRON MICROSCOPY (3.7 Å) | | Cite: | Molecular basis for the role of disulfide-linked alpha CTs in the activation of insulin-like growth factor 1 receptor and insulin receptor.
Elife, 11, 2022
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8EYR
 | | Cryo-EM structure of two IGF1 bound full-length mouse IGF1R mutant (four glycine residues inserted in the alpha-CT; IGF1R-P674G4): symmetric conformation | | Descriptor: | Insulin-like growth factor 1 receptor, Insulin-like growth factor I | | Authors: | Li, J, Wu, J.Y, Hall, C, Bai, X.C, Choi, E. | | Deposit date: | 2022-10-28 | | Release date: | 2022-11-09 | | Last modified: | 2022-12-07 | | Method: | ELECTRON MICROSCOPY (4 Å) | | Cite: | Molecular basis for the role of disulfide-linked alpha CTs in the activation of insulin-like growth factor 1 receptor and insulin receptor.
Elife, 11, 2022
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8EYX
 | | Cryo-EM structure of 4 insulins bound full-length mouse IR mutant with physically decoupled alpha CTs (C684S/C685S/C687S; denoted as IR-3CS) Asymmetric conformation 1 | | Descriptor: | Insulin, Insulin receptor | | Authors: | Li, J, Wu, J.Y, Hall, C, Bai, X.C, Choi, E. | | Deposit date: | 2022-10-29 | | Release date: | 2022-11-09 | | Last modified: | 2022-12-07 | | Method: | ELECTRON MICROSCOPY (4.5 Å) | | Cite: | Molecular basis for the role of disulfide-linked alpha CTs in the activation of insulin-like growth factor 1 receptor and insulin receptor.
Elife, 11, 2022
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