8D74

Cryo-EM structure of human CNTF signaling complex: model containing the interaction core region

Summary for 8D74

Entry DOI	10.2210/pdb8d74/pdb
EMDB information	27227
Descriptor	Interleukin-6 receptor subunit beta, Ciliary neurotrophic factor, Ciliary neurotrophic factor receptor subunit alpha, ... (6 entities in total)
Functional Keywords	cytokine signaling, cntf, cntfr alpha, gp130, lifr, cytokine
Biological source	Homo sapiens (human) More
Total number of polymer chains	4
Total formula weight	228501.83
Authors	Zhou, Y.,Franklin, M.C. (deposition date: 2022-06-07, release date: 2023-03-29)
Primary citation	Zhou, Y.,Stevis, P.E.,Cao, J.,Saotome, K.,Wu, J.,Glatman Zaretsky, A.,Haxhinasto, S.,Yancopoulos, G.D.,Murphy, A.J.,Sleeman, M.W.,Olson, W.C.,Franklin, M.C. Structural insights into the assembly of gp130 family cytokine signaling complexes. Sci Adv, 9:eade4395-eade4395, 2023 Cited by PubMed: 36930708 DOI: 10.1126/sciadv.ade4395 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.03 Å)

Structure validation