8D74
Cryo-EM structure of human CNTF signaling complex: model containing the interaction core region
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Interleukin-6 receptor subunit beta | polymer | 625 | 71233.2 | 1 | UniProt (P40189) Pfam (PF06328) Pfam (PF09240) Pfam (PF00041) In PDB | Homo sapiens (human) | IL-6 receptor subunit beta,IL-6R subunit beta,IL-6R-beta,IL-6RB,CDw130,Interleukin-6 signal transducer,Membrane glycoprotein 130,gp130,Oncostatin-M receptor subunit alpha |
2 | D | Ciliary neurotrophic factor | polymer | 214 | 24704.9 | 1 | UniProt (P26441) Pfam (PF01110) In PDB | Homo sapiens (human) | CNTF |
3 | C | Ciliary neurotrophic factor receptor subunit alpha | polymer | 320 | 35855.3 | 1 | UniProt (P26992) Pfam (PF00041) In PDB | Homo sapiens (human) | CNTF receptor subunit alpha,CNTFR-alpha |
4 | B | Leukemia inhibitory factor receptor | polymer | 817 | 92834.8 | 1 | UniProt (P42702) Pfam (PF18207) Pfam (PF17971) Pfam (PF21177) Pfam (PF00041) In PDB | Homo sapiens (human) | LIF receptor,LIF-R |
5 | E, F, G, H, I... | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 6 | In PDB GlyTouCan (G42666HT) | |||
6 | A, C | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 6 | Chemie (NAG) |
Sequence modifications
A: 23 - 619 (UniProt: P40189)
D: 1 - 186 (UniProt: P26441)
B: 45 - 833 (UniProt: P42702)
PDB | External Database | Details |
---|---|---|
Glu 620 | - | expression tag |
Gln 621 | - | expression tag |
Lys 622 | - | expression tag |
Leu 623 | - | expression tag |
Ile 624 | - | expression tag |
Ser 625 | - | expression tag |
Glu 626 | - | expression tag |
Glu 627 | - | expression tag |
Asp 628 | - | expression tag |
Leu 629 | - | expression tag |
Gly 630 | - | expression tag |
Gly 631 | - | expression tag |
Glu 632 | - | expression tag |
Gln 633 | - | expression tag |
Lys 634 | - | expression tag |
Leu 635 | - | expression tag |
Ile 636 | - | expression tag |
Ser 637 | - | expression tag |
Glu 638 | - | expression tag |
Glu 639 | - | expression tag |
Asp 640 | - | expression tag |
Leu 641 | - | expression tag |
His 642 | - | expression tag |
His 643 | - | expression tag |
His 644 | - | expression tag |
His 645 | - | expression tag |
His 646 | - | expression tag |
His 647 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Glu 187 | - | expression tag |
Gln 188 | - | expression tag |
Lys 189 | - | expression tag |
Leu 190 | - | expression tag |
Ile 191 | - | expression tag |
Ser 192 | - | expression tag |
Glu 193 | - | expression tag |
Glu 194 | - | expression tag |
Asp 195 | - | expression tag |
Leu 196 | - | expression tag |
Gly 197 | - | expression tag |
Gly 198 | - | expression tag |
Glu 199 | - | expression tag |
Gln 200 | - | expression tag |
Lys 201 | - | expression tag |
Leu 202 | - | expression tag |
Ile 203 | - | expression tag |
Ser 204 | - | expression tag |
Glu 205 | - | expression tag |
Glu 206 | - | expression tag |
Asp 207 | - | expression tag |
Leu 208 | - | expression tag |
His 209 | - | expression tag |
His 210 | - | expression tag |
His 211 | - | expression tag |
His 212 | - | expression tag |
His 213 | - | expression tag |
His 214 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Glu 834 | - | expression tag |
Gln 835 | - | expression tag |
Lys 836 | - | expression tag |
Leu 837 | - | expression tag |
Ile 838 | - | expression tag |
Ser 839 | - | expression tag |
Glu 840 | - | expression tag |
Glu 841 | - | expression tag |
Asp 842 | - | expression tag |
Leu 843 | - | expression tag |
Gly 844 | - | expression tag |
Gly 845 | - | expression tag |
Glu 846 | - | expression tag |
Gln 847 | - | expression tag |
Lys 848 | - | expression tag |
Leu 849 | - | expression tag |
Ile 850 | - | expression tag |
Ser 851 | - | expression tag |
Glu 852 | - | expression tag |
Glu 853 | - | expression tag |
Asp 854 | - | expression tag |
Leu 855 | - | expression tag |
His 856 | - | expression tag |
His 857 | - | expression tag |
His 858 | - | expression tag |
His 859 | - | expression tag |
His 860 | - | expression tag |
His 861 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 224628.2 | |
Branched | Number of molecules | 6 |
Total formula weight | 2546.4 | |
Non-Polymers* | Number of molecules | 6 |
Total formula weight | 1327.2 | |
All* | Total formula weight | 228501.8 |