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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

8D74

Cryo-EM structure of human CNTF signaling complex: model containing the interaction core region

Functional Information from GO Data
ChainGOidnamespacecontents
A0004896molecular_functioncytokine receptor activity
A0016020cellular_componentmembrane
B0004896molecular_functioncytokine receptor activity
B0016020cellular_componentmembrane
C0004896molecular_functioncytokine receptor activity
C0004897molecular_functionciliary neurotrophic factor receptor activity
C0004921molecular_functioninterleukin-11 receptor activity
C0005102molecular_functionsignaling receptor binding
C0005125molecular_functioncytokine activity
C0005515molecular_functionprotein binding
C0005615cellular_componentextracellular space
C0005886cellular_componentplasma membrane
C0007165biological_processsignal transduction
C0007399biological_processnervous system development
C0008284biological_processpositive regulation of cell population proliferation
C0009897cellular_componentexternal side of plasma membrane
C0016020cellular_componentmembrane
C0016324cellular_componentapical plasma membrane
C0019221biological_processcytokine-mediated signaling pathway
C0019898cellular_componentextrinsic component of membrane
C0019955molecular_functioncytokine binding
C0019970molecular_functioninterleukin-11 binding
C0032991cellular_componentprotein-containing complex
C0038023molecular_functionsignaling receptor activity
C0038154biological_processinterleukin-11-mediated signaling pathway
C0043524biological_processnegative regulation of neuron apoptotic process
C0070110cellular_componentciliary neurotrophic factor receptor complex
C0070120biological_processciliary neurotrophic factor-mediated signaling pathway
C0070446biological_processnegative regulation of oligodendrocyte progenitor proliferation
C0097059cellular_componentCNTFR-CLCF1 complex
C0098552cellular_componentside of membrane
C0140597molecular_functionprotein carrier chaperone
D0005125molecular_functioncytokine activity
D0005127molecular_functionciliary neurotrophic factor receptor binding
D0005138molecular_functioninterleukin-6 receptor binding
D0005515molecular_functionprotein binding
D0005576cellular_componentextracellular region
D0005615cellular_componentextracellular space
D0005737cellular_componentcytoplasm
D0007165biological_processsignal transduction
D0007259biological_processcell surface receptor signaling pathway via JAK-STAT
D0007399biological_processnervous system development
D0008083molecular_functiongrowth factor activity
D0010628biological_processpositive regulation of gene expression
D0019221biological_processcytokine-mediated signaling pathway
D0030154biological_processcell differentiation
D0030424cellular_componentaxon
D0032991cellular_componentprotein-containing complex
D0042531biological_processpositive regulation of tyrosine phosphorylation of STAT protein
D0043025cellular_componentneuronal cell body
D0043067biological_processregulation of programmed cell death
D0043524biological_processnegative regulation of neuron apoptotic process
D0044877molecular_functionprotein-containing complex binding
D0048143biological_processastrocyte activation
D0048680biological_processpositive regulation of axon regeneration
D0070120biological_processciliary neurotrophic factor-mediated signaling pathway
D0070446biological_processnegative regulation of oligodendrocyte progenitor proliferation
D0097386cellular_componentglial cell projection
D0097696biological_processcell surface receptor signaling pathway via STAT
Functional Information from PROSITE/UniProt
site_idPS01353
Number of Residues54
DetailsHEMATOPO_REC_L_F2 Long hematopoietin receptor, gp130 family signature. NlvgkSdaavltipacdfqathpvmdlkafpkdnmlw....VeWtt.Presvkk...Yi.LeW
ChainResidueDetails
AASN404-TRP457
BASN611-TRP661
site_idPS01354
Number of Residues43
DetailsHEMATOPO_REC_L_F3 Long hematopoietin receptor, soluble alpha chains family signature. VkPDPPenVvarpvpsnprrLevtWqtPsTWpdpes.FpLkFfL
ChainResidueDetails
CVAL202-LEU244
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues188
DetailsDomain: {"description":"Fibronectin type-III 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00316","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues100
DetailsDomain: {"description":"Fibronectin type-III 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00316","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues95
DetailsDomain: {"description":"Fibronectin type-III 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00316","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues12
DetailsMotif: {"description":"WSXWS motif"}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"11098061","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues1
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"11098061","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20489211","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues1
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"11098061","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues1
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"11098061","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20489211","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues1
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) (complex) asparagine","evidences":[{"source":"PubMed","id":"19139490","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues9
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues3
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"18775332","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

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PDB entries from 2025-12-24

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