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8D74

Cryo-EM structure of human CNTF signaling complex: model containing the interaction core region

Functional Information from GO Data
ChainGOidnamespacecontents
A0004896molecular_functioncytokine receptor activity
A0016020cellular_componentmembrane
B0004896molecular_functioncytokine receptor activity
B0016020cellular_componentmembrane
C0001967biological_processsuckling behavior
C0003360biological_processbrainstem development
C0004896molecular_functioncytokine receptor activity
C0004897molecular_functionciliary neurotrophic factor receptor activity
C0005102molecular_functionsignaling receptor binding
C0005515molecular_functionprotein binding
C0005886cellular_componentplasma membrane
C0007165biological_processsignal transduction
C0007399biological_processnervous system development
C0007548biological_processsex differentiation
C0008284biological_processpositive regulation of cell population proliferation
C0009897cellular_componentexternal side of plasma membrane
C0016020cellular_componentmembrane
C0016324cellular_componentapical plasma membrane
C0019221biological_processcytokine-mediated signaling pathway
C0019898cellular_componentextrinsic component of membrane
C0019955molecular_functioncytokine binding
C0043524biological_processnegative regulation of neuron apoptotic process
C0060538biological_processskeletal muscle organ development
C0070110cellular_componentciliary neurotrophic factor receptor complex
C0070120biological_processciliary neurotrophic factor-mediated signaling pathway
C0097049biological_processmotor neuron apoptotic process
C0097059cellular_componentCNTFR-CLCF1 complex
C0098552cellular_componentside of membrane
C2000672biological_processnegative regulation of motor neuron apoptotic process
D0005125molecular_functioncytokine activity
D0005127molecular_functionciliary neurotrophic factor receptor binding
D0005138molecular_functioninterleukin-6 receptor binding
D0005515molecular_functionprotein binding
D0005576cellular_componentextracellular region
D0005615cellular_componentextracellular space
D0005737cellular_componentcytoplasm
D0007165biological_processsignal transduction
D0007399biological_processnervous system development
D0008083molecular_functiongrowth factor activity
D0008284biological_processpositive regulation of cell population proliferation
D0010628biological_processpositive regulation of gene expression
D0030154biological_processcell differentiation
D0030424cellular_componentaxon
D0042531biological_processpositive regulation of tyrosine phosphorylation of STAT protein
D0043524biological_processnegative regulation of neuron apoptotic process
D0044877molecular_functionprotein-containing complex binding
D0046533biological_processnegative regulation of photoreceptor cell differentiation
D0046668biological_processregulation of retinal cell programmed cell death
D0048143biological_processastrocyte activation
D0048644biological_processmuscle organ morphogenesis
D0048666biological_processneuron development
D0048680biological_processpositive regulation of axon regeneration
D0060221biological_processretinal rod cell differentiation
D0070120biological_processciliary neurotrophic factor-mediated signaling pathway
Functional Information from PROSITE/UniProt
site_idPS01353
Number of Residues51
DetailsHEMATOPO_REC_L_F2 Long hematopoietin receptor, gp130 family signature. NsvgsSppskiasmeipnddlkieqvvgmgkgil.......LtWhydPnmtcd....Yv.IkW
ChainResidueDetails
BASN611-TRP661
AASN404-TRP457

site_idPS01354
Number of Residues43
DetailsHEMATOPO_REC_L_F3 Long hematopoietin receptor, soluble alpha chains family signature. VkPDPPenVvarpvpsnprrLevtWqtPsTWpdpes.FpLkFfL
ChainResidueDetails
CVAL202-LEU244

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues788
DetailsTOPO_DOM: Extracellular => ECO:0000255
ChainResidueDetails
BGLN45-SER833

site_idSWS_FT_FI2
Number of Residues15
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
BASN64
BASN572
BASN652
BASN663
BASN680
BASN729
BASN787
BASN85
BASN143
BASN191
BASN243
BASN390
BASN445
BASN481
BASN489

site_idSWS_FT_FI3
Number of Residues4
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:18775332
ChainResidueDetails
BASN131
BASN303
BASN407
BASN426

site_idSWS_FT_FI4
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:11098061, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:20489211
ChainResidueDetails
AASN227

site_idSWS_FT_FI5
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:11098061, ECO:0000269|PubMed:16335952
ChainResidueDetails
AASN379

site_idSWS_FT_FI6
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:11098061, ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:20489211
ChainResidueDetails
AASN383

site_idSWS_FT_FI7
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) (complex) asparagine => ECO:0000269|PubMed:19139490, ECO:0000269|PubMed:19159218
ChainResidueDetails
AASN390

222926

PDB entries from 2024-07-24

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