7YQ5

human insulin receptor bound with A62 DNA aptamer and insulin

Summary for 7YQ5

• Entry DOI: 10.2210/pdb7yq5/pdb
• EMDB information: 34020
• Descriptor: Insulin A chain, Insulin, isoform 2, IR-A62 aptamer, ... (4 entities in total)
• Functional Keywords: receptor-ligand complex_b_overall, structural protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 5
• Total formula weight: 221017.90

Authors

Kim, J.,Yunn, N.,Ryu, S.,Cho, Y. (deposition date: 2022-08-05, release date: 2022-11-09)

• Primary citation: Kim, J.,Yunn, N.O.,Park, M.,Kim, J.,Park, S.,Kim, Y.,Noh, J.,Ryu, S.H.,Cho, Y.; Functional selectivity of insulin receptor revealed by aptamer-trapped receptor structures; Nat Commun, 13:6500-, 2022; DOI: 10.1038/s41467-022-34292-8

Experimental method

ELECTRON MICROSCOPY (4.27 Å)