8EYY

Cryo-EM structure of 4 insulins bound full-length mouse IR mutant with physically decoupled alpha CTs (C684S/C685S/C687S, denoted as IR-3CS) Asymmetric conformation 2

Summary for 8EYY

• Entry DOI: 10.2210/pdb8eyy/pdb
• EMDB information: 28693 28723 28724
• Descriptor: Insulin receptor, Insulin (2 entities in total)
• Functional Keywords: insulin receptor, insulin, signaling protein
• Biological source: Mus musculus (house mouse); More
• Total number of polymer chains: 6
• Total formula weight: 354328.26

Authors

Li, J.,Wu, J.Y.,Hall, C.,Bai, X.C.,Choi, E. (deposition date: 2022-10-29, release date: 2022-11-09, Last modification date: 2022-12-07)

• Primary citation: Li, J.,Wu, J.,Hall, C.,Bai, X.C.,Choi, E.; Molecular basis for the role of disulfide-linked alpha CTs in the activation of insulin-like growth factor 1 receptor and insulin receptor.; Elife, 11:-, 2022; PubMed: 36413010; DOI: 10.7554/eLife.81286

Experimental method

ELECTRON MICROSCOPY (4.9 Å)