4NN6

Cytokine receptor complex - Crystal form 1B

Summary for 4NN6

Entry DOI	10.2210/pdb4nn6/pdb
Related	4NN5 4NN7
Descriptor	Thymic stromal lymphopoietin, Interleukin-7 receptor subunit alpha, Cytokine receptor-like factor 2, ... (4 entities in total)
Functional Keywords	four helical bundle fold, chr domains, tslp cytokine signaling, tslpr and il-7ralpha receptors, cell surface, cytokine-cytokine receptor complex, cytokine/cytokine receptor
Biological source	Mus musculus (mouse) More
Cellular location	Secreted : Q9JIE6 Membrane; Single-pass type I membrane protein: P16872 Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 3: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: Q8CII9
Total number of polymer chains	3
Total formula weight	63354.11
Authors	Verstraete, K.,van Schie, L.,Savvides, S.N. (deposition date: 2013-11-16, release date: 2014-03-19, Last modification date: 2023-09-20)
Primary citation	Verstraete, K.,van Schie, L.,Vyncke, L.,Bloch, Y.,Tavernier, J.,Pauwels, E.,Peelman, F.,Savvides, S.N. Structural basis of the proinflammatory signaling complex mediated by TSLP. Nat.Struct.Mol.Biol., 21:375-382, 2014 Cited by PubMed: 24632570 DOI: 10.1038/nsmb.2794 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.545 Å)

Structure validation