4NN6

Cytokine receptor complex - Crystal form 1B

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001961	biological_process	positive regulation of cytokine-mediated signaling pathway
A	0005125	molecular_function	cytokine activity
A	0005139	molecular_function	interleukin-7 receptor binding
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0008284	biological_process	positive regulation of cell population proliferation
A	0019221	biological_process	cytokine-mediated signaling pathway
A	0032722	biological_process	positive regulation of chemokine production
A	0032733	biological_process	positive regulation of interleukin-10 production
A	0032736	biological_process	positive regulation of interleukin-13 production
A	0032754	biological_process	positive regulation of interleukin-5 production
A	0032755	biological_process	positive regulation of interleukin-6 production
A	0033005	biological_process	positive regulation of mast cell activation
A	0038111	biological_process	interleukin-7-mediated signaling pathway
A	0043066	biological_process	negative regulation of apoptotic process
A	0050729	biological_process	positive regulation of inflammatory response
A	0050829	biological_process	defense response to Gram-negative bacterium
A	0050832	biological_process	defense response to fungus
A	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
A	0071654	biological_process	positive regulation of chemokine (C-C motif) ligand 1 production
A	0071657	biological_process	positive regulation of granulocyte colony-stimulating factor production
A	1904894	biological_process	positive regulation of receptor signaling pathway via STAT
B	0004896	molecular_function	cytokine receptor activity
B	0016020	cellular_component	membrane

Functional Information from PROSITE/UniProt

site_id	PS01355
Number of Residues	33
Details	HEMATOPO_REC_S_F1 Short hematopoietin receptor family 1 signature. LrpkamyeikVRsiphndyfkgf.........WSeWSpsstF

Chain	Residue	Details
B	LEU195-PHE227

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Site: {"description":"Inserts into a conserved IL7R hydrophobic pocket, important for IL7R-binding","evidences":[{"source":"PubMed","id":"24632570","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	6
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	101
Details	Domain: {"description":"Fibronectin type-III","evidences":[{"source":"PROSITE-ProRule","id":"PRU00316","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	8
Details	Motif: {"description":"WSXWS motif"}

Chain

Residue

Details

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