4NN6

Cytokine receptor complex - Crystal form 1B

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Thymic stromal lymphopoietin	polymer	130	15109.9	1	UniProt (Q9JIE6) Pfam (PF15216)	Mus musculus (mouse)	TSLP, Thymic stroma-derived lymphopoietin
2	B (B)	Interleukin-7 receptor subunit alpha	polymer	223	25431.8	1	UniProt (P16872) Pfam (PF18447)	Mus musculus (mouse)	IL-7 receptor subunit alpha, IL-7R subunit alpha, IL-7R-alpha, IL-7RA
3	C (C)	Cytokine receptor-like factor 2	polymer	212	22812.4	1	UniProt (Q8CII9) Pfam (PF22012) Pfam (PF21605)	Mus musculus (mouse)	Cytokine receptor-like molecule 2, CRLM-2, Thymic stromal lymphopoietin protein receptor, TSLP receptor, TSLPR, Type I cytokine receptor delta 1
4	D, E (B, C)	water	water		18.0	3	Chemie (HOH)

Sequence modifications

A: 20 - 140 (UniProt: Q9JIE6)

PDB	External Database	Details
Gln 123	Asn 123	engineered mutation
Gly 141	-	expression tag
Thr 142	-	expression tag
Lys 143	-	expression tag
His 144	-	expression tag
His 145	-	expression tag
His 146	-	expression tag
His 147	-	expression tag
His 148	-	expression tag
His 149	-	expression tag

B: 21 - 239 (UniProt: P16872)

PDB	External Database	Details
Gly 17	-	expression tag
Ser 18	-	expression tag
His 19	-	expression tag
Met 20	-	expression tag

C: 20 - 222 (UniProt: Q8CII9)

PDB	External Database	Details
Gln 122	Asn 122	engineered mutation
Val 179	Ala 179	conflict
Gly 223	-	expression tag
Thr 224	-	expression tag
Lys 225	-	expression tag
His 226	-	expression tag
His 227	-	expression tag
His 228	-	expression tag
His 229	-	expression tag
His 230	-	expression tag
His 231	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	63354.1
All*	Total formula weight	63354.1

*Water molecules are not included.