8EYR

Cryo-EM structure of two IGF1 bound full-length mouse IGF1R mutant (four glycine residues inserted in the alpha-CT; IGF1R-P674G4): symmetric conformation

Summary for 8EYR

• Entry DOI: 10.2210/pdb8eyr/pdb
• EMDB information: 28693
• Descriptor: Insulin-like growth factor 1 receptor, Insulin-like growth factor I (2 entities in total)
• Functional Keywords: igf1r, igf1, signaling protein
• Biological source: Mus musculus (house mouse); More
• Total number of polymer chains: 4
• Total formula weight: 332726.55

Authors

Li, J.,Wu, J.Y.,Hall, C.,Bai, X.C.,Choi, E. (deposition date: 2022-10-28, release date: 2022-11-09, Last modification date: 2022-12-07)

• Primary citation: Li, J.,Wu, J.,Hall, C.,Bai, X.C.,Choi, E.; Molecular basis for the role of disulfide-linked alpha CTs in the activation of insulin-like growth factor 1 receptor and insulin receptor.; Elife, 11:-, 2022; PubMed: 36413010; DOI: 10.7554/eLife.81286

Experimental method

ELECTRON MICROSCOPY (4 Å)