8EYR
Cryo-EM structure of two IGF1 bound full-length mouse IGF1R mutant (four glycine residues inserted in the alpha-CT; IGF1R-P674G4): symmetric conformation
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (B, A) | Insulin-like growth factor 1 receptor | polymer | 1266 | 144482.0 | 2 | UniProt (Q60751) Pfam (PF01030) Pfam (PF00757) Pfam (PF07714) | Mus musculus (house mouse) | Insulin-like growth factor I receptor,IGF-I receptor |
| 2 | C, D (C, D) | Insulin-like growth factor I | polymer | 195 | 21881.3 | 2 | UniProt (P05019) Pfam (PF00049) | Homo sapiens (human) | IGF-I,Mechano growth factor,MGF,Somatomedin-C |
Sequence modifications
B, A: 1 - 1266 (UniProt: Q60751)
| PDB | External Database | Details |
|---|---|---|
| Gly 675 | - | insertion |
| Gly 676 | - | insertion |
| Gly 677 | - | insertion |
| Gly 678 | - | insertion |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 332726.5 | |
| All* | Total formula weight | 332726.5 |
