8DPT

The structure of the IL-11 signalling complex, with full-length extracellular gp130

Summary for 8DPT

• Entry DOI: 10.2210/pdb8dpt/pdb
• EMDB information: 27642
• Descriptor: Interleukin-6 receptor subunit beta, Interleukin-11, Interleukin-11 receptor subunit alpha, ... (6 entities in total)
• Functional Keywords: complex, gp130, glycoprotein 130, signalling, cancer, cytokine
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 6
• Total formula weight: 238268.97

Authors

Metcalfe, R.D.,Hanssen, E.,Griffin, M.D.W. (deposition date: 2022-07-17, release date: 2023-11-29)

• Primary citation: Metcalfe, R.D.,Hanssen, E.,Fung, K.Y.,Aizel, K.,Kosasih, C.C.,Zlatic, C.O.,Doughty, L.,Morton, C.J.,Leis, A.P.,Parker, M.W.,Gooley, P.R.,Putoczki, T.L.,Griffin, M.D.W.; Structures of the interleukin 11 signalling complex reveal gp130 dynamics and the inhibitory mechanism of a cytokine variant; Nat Commun, 14:7543-, 2023; DOI: 10.1038/s41467-023-42754-w

Experimental method

ELECTRON MICROSCOPY (4 Å)