8DPT
The structure of the IL-11 signalling complex, with full-length extracellular gp130
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004896 | molecular_function | cytokine receptor activity |
| A | 0016020 | cellular_component | membrane |
| B | 0005125 | molecular_function | cytokine activity |
| B | 0005142 | molecular_function | interleukin-11 receptor binding |
| B | 0005515 | molecular_function | protein binding |
| B | 0005576 | cellular_component | extracellular region |
| B | 0005615 | cellular_component | extracellular space |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0008083 | molecular_function | growth factor activity |
| B | 0008283 | biological_process | cell population proliferation |
| B | 0008284 | biological_process | positive regulation of cell population proliferation |
| B | 0030183 | biological_process | B cell differentiation |
| B | 0030219 | biological_process | megakaryocyte differentiation |
| B | 0033138 | biological_process | positive regulation of peptidyl-serine phosphorylation |
| B | 0038154 | biological_process | interleukin-11-mediated signaling pathway |
| B | 0043410 | biological_process | positive regulation of MAPK cascade |
| B | 0045444 | biological_process | fat cell differentiation |
| B | 0045944 | biological_process | positive regulation of transcription by RNA polymerase II |
| B | 0046888 | biological_process | negative regulation of hormone secretion |
| B | 0050731 | biological_process | positive regulation of peptidyl-tyrosine phosphorylation |
| B | 1903659 | biological_process | regulation of complement-dependent cytotoxicity |
| B | 2000352 | biological_process | negative regulation of endothelial cell apoptotic process |
| C | 0004896 | molecular_function | cytokine receptor activity |
| C | 0016020 | cellular_component | membrane |
| D | 0004896 | molecular_function | cytokine receptor activity |
| D | 0016020 | cellular_component | membrane |
| E | 0005125 | molecular_function | cytokine activity |
| E | 0005142 | molecular_function | interleukin-11 receptor binding |
| E | 0005515 | molecular_function | protein binding |
| E | 0005576 | cellular_component | extracellular region |
| E | 0005615 | cellular_component | extracellular space |
| E | 0005737 | cellular_component | cytoplasm |
| E | 0008083 | molecular_function | growth factor activity |
| E | 0008283 | biological_process | cell population proliferation |
| E | 0008284 | biological_process | positive regulation of cell population proliferation |
| E | 0030183 | biological_process | B cell differentiation |
| E | 0030219 | biological_process | megakaryocyte differentiation |
| E | 0033138 | biological_process | positive regulation of peptidyl-serine phosphorylation |
| E | 0038154 | biological_process | interleukin-11-mediated signaling pathway |
| E | 0043410 | biological_process | positive regulation of MAPK cascade |
| E | 0045444 | biological_process | fat cell differentiation |
| E | 0045944 | biological_process | positive regulation of transcription by RNA polymerase II |
| E | 0046888 | biological_process | negative regulation of hormone secretion |
| E | 0050731 | biological_process | positive regulation of peptidyl-tyrosine phosphorylation |
| E | 1903659 | biological_process | regulation of complement-dependent cytotoxicity |
| E | 2000352 | biological_process | negative regulation of endothelial cell apoptotic process |
| F | 0004896 | molecular_function | cytokine receptor activity |
| F | 0016020 | cellular_component | membrane |
Functional Information from PROSITE/UniProt
| site_id | PS01353 |
| Number of Residues | 54 |
| Details | HEMATOPO_REC_L_F2 Long hematopoietin receptor, gp130 family signature. NlvgkSdaavltipacdfqathpvmdlkafpkdnmlw....VeWtt.Presvkk...Yi.LeW |
| Chain | Residue | Details |
| A | ASN382-TRP435 |
| site_id | PS01354 |
| Number of Residues | 43 |
| Details | HEMATOPO_REC_L_F3 Long hematopoietin receptor, soluble alpha chains family signature. LrPDPPqgLrvesvpgyprrLrasWtyPaSWpsqph.FlLkFrL |
| Chain | Residue | Details |
| C | LEU194-LEU236 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 354 |
| Details | Domain: {"description":"Ig-like C2-type"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 396 |
| Details | Domain: {"description":"Fibronectin type-III 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00316","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 394 |
| Details | Domain: {"description":"Fibronectin type-III 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00316","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 16 |
| Details | Motif: {"description":"WSXWS motif"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"11098061","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20489211","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"11098061","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"11098061","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20489211","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"11098061","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"11098061","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20489211","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) (complex) asparagine","evidences":[{"source":"PubMed","id":"19139490","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 16 |
| Details | Region: {"description":"Important for interaction with IL11RA and for the stimulation of cell proliferation","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 2 |
| Details | Site: {"description":"Important for interaction with IL6ST and for the stimulation of cell proliferation","evidences":[{"source":"UniProtKB","id":"P47873","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 4 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
