8DPT

The structure of the IL-11 signalling complex, with full-length extracellular gp130

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, D (A, D)	Interleukin-6 receptor subunit beta	polymer	591	67199.8	2	UniProt (P40189) Pfam (PF06328) Pfam (PF09240) Pfam (PF00041)	Homo sapiens (human)	IL-6 receptor subunit beta,IL-6R subunit beta,IL-6R-beta,IL-6RB,CDw130,Interleukin-6 signal transducer,Membrane glycoprotein 130,gp130,Oncostatin-M receptor subunit alpha
2	B, E (B, E)	Interleukin-11	polymer	169	18273.3	2	UniProt (P20809) Pfam (PF07400)	Homo sapiens (human)	IL-11,Adipogenesis inhibitory factor,AGIF
3	C, F (C, F)	Interleukin-11 receptor subunit alpha	polymer	298	32208.0	2	UniProt (Q14626)	Homo sapiens (human)	IL-11 receptor subunit alpha,IL-11R subunit alpha,IL-11R-alpha,IL-11RA
4	G, H (I, L)	beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		586.5	2	In PDB GlyTouCan (G15407YE)
5	I, J (G, H)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	2	In PDB GlyTouCan (G42666HT)
6	K, L, M, N (A, D)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	4	Chemie (NAG)

Sequence modifications

B, E: 11 - 178 (UniProt: P20809)

PDB	External Database	Details
Gly 10	-	expression tag

C, F: 1 - 297 (UniProt: Q14626)

PDB	External Database	Details
Gly 0	-	expression tag
Ser 226	Cys 248	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	235362.3
Branched	Number of molecules	4
	Total formula weight	2021.9
Non-Polymers*	Number of molecules	4
	Total formula weight	884.8
All*	Total formula weight	238269.0

*Water molecules are not included.