1YVJ
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![BU of 1yvj by Molmil](/molmil-images/mine/1yvj) | Crystal structure of the Jak3 kinase domain in complex with a staurosporine analogue | Descriptor: | (2S,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL, 1,2,3,4-TETRAHYDROGEN-STAUROSPORINE, Tyrosine-protein kinase JAK3 | Authors: | Boggon, T.J, Li, Y, Manley, P.W, Eck, M.J. | Deposit date: | 2005-02-15 | Release date: | 2005-05-24 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.55 Å) | Cite: | Crystal structure of the Jak3 kinase domain in complex with a staurosporine analog Blood, 106, 2005
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1R0P
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![BU of 1r0p by Molmil](/molmil-images/mine/1r0p) | Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor c-Met in complex with the microbial alkaloid K-252a | Descriptor: | Hepatocyte growth factor receptor, K-252A | Authors: | Schiering, N, Knapp, S, Marconi, M, Flocco, M.M, Cui, J, Perego, R, Rusconi, L, Cristiani, C. | Deposit date: | 2003-09-22 | Release date: | 2003-10-07 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor c-Met and its complex with the microbial alkaloid K-252a Proc.Natl.Acad.Sci.USA, 100, 2003
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1IEP
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![BU of 1iep by Molmil](/molmil-images/mine/1iep) | CRYSTAL STRUCTURE OF THE C-ABL KINASE DOMAIN IN COMPLEX WITH STI-571. | Descriptor: | 4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)-PHENYL]-BENZAMIDE, CHLORIDE ION, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ABL | Authors: | Nagar, B, Bornmann, W, Schindler, T, Clarkson, B, Kuriyan, J. | Deposit date: | 2001-04-10 | Release date: | 2001-04-18 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Crystal structures of the kinase domain of c-Abl in complex with the small molecule inhibitors PD173955 and imatinib (STI-571) Cancer Res., 62, 2002
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1IRK
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![BU of 1irk by Molmil](/molmil-images/mine/1irk) | CRYSTAL STRUCTURE OF THE TYROSINE KINASE DOMAIN OF THE HUMAN INSULIN RECEPTOR | Descriptor: | ETHYL MERCURY ION, INSULIN RECEPTOR TYROSINE KINASE DOMAIN | Authors: | Hubbard, S.R, Wei, L, Ellis, L, Hendrickson, W.A. | Deposit date: | 1995-01-02 | Release date: | 1995-02-27 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Crystal structure of the tyrosine kinase domain of the human insulin receptor. Nature, 372, 1994
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1U4D
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![BU of 1u4d by Molmil](/molmil-images/mine/1u4d) | Structure of the ACK1 Kinase Domain bound to Debromohymenialdisine | Descriptor: | Activated CDC42 kinase 1, CHLORIDE ION, DEBROMOHYMENIALDISINE | Authors: | Lougheed, J.C, Chen, R.H, Mak, P, Stout, T.J. | Deposit date: | 2004-07-23 | Release date: | 2004-08-31 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Crystal Structures of the Phosphorylated and Unphosphorylated Kinase Domains of the Cdc42-associated Tyrosine Kinase ACK1. J.Biol.Chem., 279, 2004
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1JQH
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![BU of 1jqh by Molmil](/molmil-images/mine/1jqh) | IGF-1 receptor kinase domain | Descriptor: | IGF-1 receptor kinase, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | Authors: | Pautsch, A, Zoephel, A, Ahorn, H, Spevak, W, Hauptmann, R, Nar, H. | Deposit date: | 2001-08-07 | Release date: | 2002-04-19 | Last modified: | 2021-11-10 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Crystal structure of bisphosphorylated IGF-1 receptor kinase: insight into domain movements upon kinase activation. Structure, 9, 2001
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1R1W
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![BU of 1r1w by Molmil](/molmil-images/mine/1r1w) | CRYSTAL STRUCTURE OF THE TYROSINE KINASE DOMAIN OF THE HEPATOCYTE GROWTH FACTOR RECEPTOR C-MET | Descriptor: | HEPATOCYTE GROWTH FACTOR RECEPTOR | Authors: | Schiering, N, Knapp, S, Marconi, M, Flocco, M.M, Cui, J, Perego, R, Rusconi, L, Cristiani, C. | Deposit date: | 2003-09-25 | Release date: | 2003-10-07 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor c-Met and its complex with the microbial alkaloid K-252a Proc.Natl.Acad.Sci.USA, 100, 2003
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1T46
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![BU of 1t46 by Molmil](/molmil-images/mine/1t46) | STRUCTURAL BASIS FOR THE AUTOINHIBITION AND STI-571 INHIBITION OF C-KIT TYROSINE KINASE | Descriptor: | 4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)-PHENYL]-BENZAMIDE, Homo sapiens v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog, PHOSPHATE ION | Authors: | Mol, C.D, Dougan, D.R, Schneider, T.R, Skene, R.J, Kraus, M.L, Scheibe, D.N, Snell, G.P, Zou, H, Sang, B.C, Wilson, K.P. | Deposit date: | 2004-04-28 | Release date: | 2004-06-15 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Structural basis for the autoinhibition and STI-571 inhibition of c-Kit tyrosine kinase. J.Biol.Chem., 279, 2004
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1U46
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![BU of 1u46 by Molmil](/molmil-images/mine/1u46) | Crystal Structure of the Unphosphorylated Kinase Domain of the Tyrosine Kinase ACK1 | Descriptor: | Activated CDC42 kinase 1, CHLORIDE ION | Authors: | Lougheed, J.C, Chen, R.H, Mak, P, Stout, T.J. | Deposit date: | 2004-07-23 | Release date: | 2004-08-31 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal Structures of the Phosphorylated and Unphosphorylated Kinase Domains of the Cdc42-associated Tyrosine Kinase ACK1. J.Biol.Chem., 279, 2004
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1U59
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![BU of 1u59 by Molmil](/molmil-images/mine/1u59) | Crystal Structure of the ZAP-70 Kinase Domain in Complex with Staurosporine | Descriptor: | STAUROSPORINE, Tyrosine-protein kinase ZAP-70 | Authors: | Jin, L, Pluskey, S, Petrella, E.C, Cantin, S.M, Gorga, J.C, Rynkiewicz, M.J, Pandey, P, Strickler, J.E, Babine, R.E, Weaver, D.T, Seidl, K.J. | Deposit date: | 2004-07-27 | Release date: | 2004-08-17 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | The Three-dimensional Structure of the ZAP-70 Kinase Domain in Complex with Staurosporine: IMPLICATIONS FOR THE DESIGN OF SELECTIVE INHIBITORS J.Biol.Chem., 279, 2004
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1U54
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![BU of 1u54 by Molmil](/molmil-images/mine/1u54) | Crystal Structures of the Phosphorylated and Unphosphorylated Kinase Domains of the CDC42-associated Tyrosine Kinase ACK1 bound to AMP-PCP | Descriptor: | Activated CDC42 kinase 1, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER | Authors: | Lougheed, J.C, Chen, R.H, Mak, P, Stout, T.J. | Deposit date: | 2004-07-26 | Release date: | 2004-08-31 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Crystal Structures of the Phosphorylated and Unphosphorylated Kinase Domains of the Cdc42-associated Tyrosine Kinase ACK1. J.Biol.Chem., 279, 2004
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1I44
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![BU of 1i44 by Molmil](/molmil-images/mine/1i44) | CRYSTALLOGRAPHIC STUDIES OF AN ACTIVATION LOOP MUTANT OF THE INSULIN RECEPTOR TYROSINE KINASE | Descriptor: | INSULIN RECEPTOR, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER | Authors: | Till, J.H, Ablooglu, A.J, Frankel, M, Kohanski, R.A, Hubbard, S.R. | Deposit date: | 2001-02-19 | Release date: | 2001-03-07 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Crystallographic and solution studies of an activation loop mutant of the insulin receptor tyrosine kinase: insights into kinase mechanism. J.Biol.Chem., 276, 2001
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1T45
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![BU of 1t45 by Molmil](/molmil-images/mine/1t45) | STRUCTURAL BASIS FOR THE AUTOINHIBITION AND STI-571 INHIBITION OF C-KIT TYROSINE KINASE | Descriptor: | Homo sapiens v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog | Authors: | Mol, C.D, Dougan, D.R, Schneider, T.R, Skene, R.J, Kraus, M.L, Scheibe, D.N, Snell, G.P, Zou, H, Sang, B.C, Wilson, K.P. | Deposit date: | 2004-04-28 | Release date: | 2004-06-15 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural basis for the autoinhibition and STI-571 inhibition of c-Kit tyrosine kinase. J.Biol.Chem., 279, 2004
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1RJB
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![BU of 1rjb by Molmil](/molmil-images/mine/1rjb) | Crystal Structure of FLT3 | Descriptor: | FL cytokine receptor | Authors: | Griffith, J, Black, J, Faerman, C, Swenson, L, Wynn, M, Lu, F, Lippke, J, Saxena, K. | Deposit date: | 2003-11-19 | Release date: | 2004-02-03 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | The structural basis for autoinhibition of FLT3 by the juxtamembrane domain. Mol.Cell, 13, 2004
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1K2P
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![BU of 1k2p by Molmil](/molmil-images/mine/1k2p) | Crystal structure of Bruton's tyrosine kinase domain | Descriptor: | Tyrosine-protein kinase BTK | Authors: | Mao, C, Zhou, M, Uckun, F.M. | Deposit date: | 2001-09-28 | Release date: | 2002-06-26 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Crystal structure of Bruton's tyrosine kinase domain suggests a novel pathway for activation and provides insights into the molecular basis of X-linked agammaglobulinemia. J.Biol.Chem., 276, 2001
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1SM2
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![BU of 1sm2 by Molmil](/molmil-images/mine/1sm2) | Crystal structure of the phosphorylated Interleukin-2 tyrosine kinase catalytic domain | Descriptor: | STAUROSPORINE, Tyrosine-protein kinase ITK/TSK | Authors: | Brown, K, Long, J.M, Vial, S.C.M, Dedi, N, Dunster, N.J, Renwick, S.B, Tanner, A.J, Frantz, J.D, Fleming, M.A, Cheetham, G.M.T. | Deposit date: | 2004-03-08 | Release date: | 2004-07-16 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Crystal structures of interleukin-2 tyrosine kinase and their implications for the design of selective inhibitors. J.Biol.Chem., 279, 2004
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1SNX
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![BU of 1snx by Molmil](/molmil-images/mine/1snx) | CRYSTAL STRUCTURE OF APO INTERLEUKIN-2 TYROSINE KINASE CATALYTIC DOMAIN | Descriptor: | Tyrosine-protein kinase ITK/TSK | Authors: | Brown, K, Long, J.M, Vial, S.C, Dedi, N, Dunster, N.J, Renwick, S.B, Tanner, A.J, Frantz, J.D, Fleming, M.A, Cheetham, G.M.T. | Deposit date: | 2004-03-12 | Release date: | 2004-07-20 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Crystal structures of interleukin-2 tyrosine kinase and their implications for the design of selective inhibitors. J.Biol.Chem., 279, 2004
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1IR3
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![BU of 1ir3 by Molmil](/molmil-images/mine/1ir3) | |
1SNU
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![BU of 1snu by Molmil](/molmil-images/mine/1snu) | CRYSTAL STRUCTURE OF THE UNPHOSPHORYLATED INTERLEUKIN-2 TYROSINE KINASE CATALYTIC DOMAIN | Descriptor: | STAUROSPORINE, Tyrosine-protein kinase ITK/TSK | Authors: | Brown, K, Long, J.M, Vial, S.C, Dedi, N, Dunster, N.J, Renwick, S.B, Tanner, A.J, Frantz, J.D, Fleming, M.A, Cheetham, G.M.T. | Deposit date: | 2004-03-12 | Release date: | 2004-07-20 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Crystal structures of interleukin-2 tyrosine kinase and their implications for the design of selective inhibitors. J.Biol.Chem., 279, 2004
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1K3A
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![BU of 1k3a by Molmil](/molmil-images/mine/1k3a) | Structure of the Insulin-like Growth Factor 1 Receptor Kinase | Descriptor: | PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, insulin receptor substrate 1, insulin-like growth factor 1 receptor | Authors: | Favelyukis, S, Till, J.H, Hubbard, S.R, Miller, W.T. | Deposit date: | 2001-10-02 | Release date: | 2001-11-28 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structure and autoregulation of the insulin-like growth factor 1 receptor kinase. Nat.Struct.Biol., 8, 2001
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1LUF
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![BU of 1luf by Molmil](/molmil-images/mine/1luf) | Crystal Structure of the MuSK Tyrosine Kinase: Insights into Receptor Autoregulation | Descriptor: | muscle-specific tyrosine kinase receptor musk | Authors: | Till, J.H, Becerra, M, Watty, A, Lu, Y, Ma, Y, Neubert, T.A, Burden, S.J, Hubbard, S.R. | Deposit date: | 2002-05-22 | Release date: | 2002-09-11 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Crystal structure of the MuSK tyrosine kinase: insights into receptor autoregulation. Structure, 10, 2002
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1UWH
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![BU of 1uwh by Molmil](/molmil-images/mine/1uwh) | The complex of wild type B-RAF and BAY439006. | Descriptor: | 4-{4-[({[4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL]AMINO}CARBONYL)AMINO]PHENOXY}-N-METHYLPYRIDINE-2-CARBOXAMIDE, B-RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE, CHLORIDE ION | Authors: | Barford, D, Roe, S.M, Wan, P.T.C, Cancer Genome Project | Deposit date: | 2004-02-05 | Release date: | 2004-03-19 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.95 Å) | Cite: | Mechanism of Activation of the Raf-Erk Signaling Pathway by Oncogenic Mutations of B-Raf Cell(Cambridge,Mass.), 116, 2004
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1M7N
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![BU of 1m7n by Molmil](/molmil-images/mine/1m7n) | |
1UWJ
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![BU of 1uwj by Molmil](/molmil-images/mine/1uwj) | The complex of mutant V599E B-RAF and BAY439006. | Descriptor: | 4-{4-[({[4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL]AMINO}CARBONYL)AMINO]PHENOXY}-N-METHYLPYRIDINE-2-CARBOXAMIDE, B-RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE | Authors: | Barford, D, Roe, S.M, Wan, P.T.C, Cancer Genome Project | Deposit date: | 2004-02-05 | Release date: | 2004-03-19 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | Mechanism of Activation of the Raf-Erk Signaling Pathway by Oncogenic Mutations of B-Raf Cell(Cambridge,Mass.), 116, 2004
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1M17
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![BU of 1m17 by Molmil](/molmil-images/mine/1m17) | |