1YVJ

Crystal structure of the Jak3 kinase domain in complex with a staurosporine analogue

Summary for 1YVJ

DescriptorTyrosine-protein kinase JAK3, (2S,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL, 1,2,3,4-TETRAHYDROGEN-STAUROSPORINE, ... (4 entities in total)
Functional Keywordstyrosine kinase; scid; severe combined immunodeficiency; stat5; stat6; interleukin-2; common-gamma chain, transferase
Biological sourceHomo sapiens (human)
Cellular locationEndomembrane system; Peripheral membrane protein (By similarity) P52333
Total number of polymer chains1
Total molecular weight33981.97
Authors
Boggon, T.J.,Li, Y.,Manley, P.W.,Eck, M.J. (deposition date: 2005-02-15, release date: 2005-05-24, Last modification date: 2011-07-13)
Primary citation
Boggon, T.J.,Li, Y.,Manley, P.W.,Eck, M.J.
Crystal structure of the Jak3 kinase domain in complex with a staurosporine analog
Blood, 106:996-1002, 2005
PubMed: 15831699 (PDB entries with the same primary citation)
DOI: 10.1182/blood-2005-02-0707
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.55 Å)
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Structure validation

ClashscoreRamachandran outliersSidechain outliers284.5%5.2%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

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