1YVJ
Crystal structure of the Jak3 kinase domain in complex with a staurosporine analogue
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Tyrosine-protein kinase JAK3 | polymer | 290 | 33202.9 | 1 | UniProt (P52333) Pfam (PF07714) | Homo sapiens (human) | Janus kinase 3; JAK-3; JAK3; Leukocyte janus kinase; L-JAK |
| 2 | B, C (A) | (2S,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL | non-polymer | 154.3 | 2 | Chemie (DTV) | |||
| 3 | D (A) | 1,2,3,4-TETRAHYDROGEN-STAUROSPORINE | non-polymer | 470.6 | 1 | Chemie (4ST) | |||
| 4 | E (A) | water | water | 18.0 | 165 | Chemie (HOH) |
Sequence modifications
A: 814 - 1103 (UniProt: P52333)
| PDB | External Database | Details |
|---|---|---|
| Arg 895 | Glu 895 | conflict |
| Ptr 980 | Tyr 980 | modified residue |
| Ptr 981 | Tyr 981 | modified residue |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 33202.9 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 779.1 | |
| All* | Total formula weight | 33982.0 |
