1IEP

CRYSTAL STRUCTURE OF THE C-ABL KINASE DOMAIN IN COMPLEX WITH STI-571.

Summary for 1IEP

Related1FPU
DescriptorPROTO-ONCOGENE TYROSINE-PROTEIN KINASE ABL, CHLORIDE ION, 4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)-PHENYL]-BENZAMIDE, ... (4 entities in total)
Functional Keywordskinase, kinase inhibitor, sti-571, activation loop, transferase
Biological sourceMus musculus (house mouse)
Cellular locationCytoplasm, cytoskeleton P00520
Total number of polymer chains2
Total molecular weight68686.97
Authors
Nagar, B.,Bornmann, W.,Schindler, T.,Clarkson, B.,Kuriyan, J. (deposition date: 2001-04-10, release date: 2001-04-18, Last modification date: 2011-07-13)
Primary citation
Nagar, B.,Bornmann, W.,Pellicena, P.,Schindler, T.,Veach, D.R.,Miller, W.T.,Clarkson, B.,Kuriyan, J.
Crystal structures of the kinase domain of c-Abl in complex with the small molecule inhibitors PD173955 and imatinib (STI-571)
Cancer Res., 62:4236-4243, 2002
PubMed: 12154025 (PDB entries with the same primary citation)
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.1 Å)
NMR Information
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.264151.3%2.9%15.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

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More Biological unit images

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(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (1iep.pdb1.gz [50.5 KB])
Coordinate files for Biological unit (1iep.pdb2.gz [49.96 KB])