1FPU

CRYSTAL STRUCTURE OF ABL KINASE DOMAIN IN COMPLEX WITH A SMALL MOLECULE INHIBITOR

Summary for 1FPU

Entry DOI	10.2210/pdb1fpu/pdb
Descriptor	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ABL, N-[4-METHYL-3-[[4-(3-PYRIDINYL)-2-PYRIMIDINYL]AMINO]PHENYL]-3-PYRIDINECARBOXAMIDE (3 entities in total)
Functional Keywords	kinase, kinase inhibitor, sti-571, activation loop, transferase
Biological source	Mus musculus (house mouse)
Cellular location	Cytoplasm, cytoskeleton: P00520
Total number of polymer chains	2
Total formula weight	68251.88
Authors	Schindler, T.,Bornmann, W.,Pellicena, P.,Miller, W.T.,Clarkson, B.,Kuriyan, J. (deposition date: 2000-08-31, release date: 2000-09-20, Last modification date: 2024-03-13)
Primary citation	Schindler, T.,Bornmann, W.,Pellicena, P.,Miller, W.T.,Clarkson, B.,Kuriyan, J. Structural mechanism for STI-571 inhibition of abelson tyrosine kinase. Science, 289:1938-1942, 2000 Cited by PubMed: 10988075 DOI: 10.1126/science.289.5486.1938 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation