1FPU
CRYSTAL STRUCTURE OF ABL KINASE DOMAIN IN COMPLEX WITH A SMALL MOLECULE INHIBITOR
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ABL | polymer | 293 | 33743.5 | 2 | UniProt (P00520) Pfam (PF07714) | Mus musculus (house mouse) | P150, C-ABL |
| 2 | C, D (A, B) | N-[4-METHYL-3-[[4-(3-PYRIDINYL)-2-PYRIMIDINYL]AMINO]PHENYL]-3-PYRIDINECARBOXAMIDE | non-polymer | 382.4 | 2 | Chemie (PRC) | |||
| 3 | E, F (A, B) | water | water | 18.0 | 99 | Chemie (HOH) |
Sequence modifications
A, B: 229 - 515 (UniProt: P00520)
| PDB | External Database | Details |
|---|---|---|
| Gly 223 | - | cloning artifact |
| Ala 224 | - | cloning artifact |
| Met 225 | - | cloning artifact |
| Asp 226 | - | cloning artifact |
| Pro 227 | - | cloning artifact |
| Ser 228 | - | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 67487.0 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 764.8 | |
| All* | Total formula weight | 68251.9 |
