1IEP
CRYSTAL STRUCTURE OF THE C-ABL KINASE DOMAIN IN COMPLEX WITH STI-571.
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ABL | polymer | 293 | 33743.5 | 2 | UniProt (P00520) Pfam (PF07714) In PDB | Mus musculus (house mouse) | P150, C-ABL |
2 | A, B | CHLORIDE ION | non-polymer | 35.5 | 6 | Chemie (CL) | |||
3 | A, B | 4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)-PHENYL]-BENZAMIDE | non-polymer | 493.6 | 2 | Chemie (STI) | |||
4 | water | water | 18.0 | 172 | Chemie (HOH) |
Sequence modifications
A, B: 229 - 515 (UniProt: P00520)
PDB | External Database | Details |
---|---|---|
Gly 223 | - | cloning artifact |
Ala 224 | - | cloning artifact |
Met 225 | - | cloning artifact |
Asp 226 | - | cloning artifact |
Pro 227 | - | cloning artifact |
Ser 228 | - | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 67487.0 | |
Non-Polymers* | Number of molecules | 8 |
Total formula weight | 1199.9 | |
All* | Total formula weight | 68687.0 |