1UWH

The complex of wild type B-RAF and BAY439006.

Summary for 1UWH

Related1UWJ
DescriptorB-RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE, 4-{4-[({[4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL]AMINO}CARBONYL)AMINO]PHENOXY}-N-METHYLPYRIDINE-2-CARBOXAMIDE, CHLORIDE ION, ... (4 entities in total)
Functional Keywordstransferase
Biological sourceHOMO SAPIENS (HUMAN)
Cellular locationNucleus  P15056
Total number of polymer chains2
Total molecular weight63809.92
Authors
Barford, D.,Roe, S.M.,Wan, P.T.C.,Cancer Genome Project (deposition date: 2004-02-05, release date: 2004-03-19, Last modification date: 2018-01-17)
Primary citation
Wan, P.T.C.,Garnett, M.J.,Roe, S.M.,Lee, S.,Niculescu-Duvaz, D.,Good, V.M.,Jones, C.M.,Marshall, C.J.,Springer, C.J.,Barford, D.,Marais, R.
Mechanism of Activation of the Raf-Erk Signaling Pathway by Oncogenic Mutations of B-Raf
Cell(Cambridge,Mass.), 116:855-, 2004
PubMed: 15035987 (PDB entries with the same primary citation)
DOI: 10.1016/S0092-8674(04)00215-6
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.95 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.25117 3.1% 4.4% 7.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
171588
PDB entries from 2020-11-25