1SNU

CRYSTAL STRUCTURE OF THE UNPHOSPHORYLATED INTERLEUKIN-2 TYROSINE KINASE CATALYTIC DOMAIN

Summary for 1SNU

Entry DOI	10.2210/pdb1snu/pdb
Related	1SM2 1SNX
Descriptor	Tyrosine-protein kinase ITK/TSK, STAUROSPORINE (3 entities in total)
Functional Keywords	protein kinase, immunology, transferase
Biological source	Homo sapiens (human)
Cellular location	Cell membrane (By similarity): Q08881
Total number of polymer chains	2
Total formula weight	61141.91
Authors	Brown, K.,Long, J.M.,Vial, S.C.,Dedi, N.,Dunster, N.J.,Renwick, S.B.,Tanner, A.J.,Frantz, J.D.,Fleming, M.A.,Cheetham, G.M.T. (deposition date: 2004-03-12, release date: 2004-07-20, Last modification date: 2023-08-23)
Primary citation	Brown, K.,Long, J.M.,Vial, S.C.,Dedi, N.,Dunster, N.J.,Renwick, S.B.,Tanner, A.J.,Frantz, J.D.,Fleming, M.A.,Cheetham, G.M. Crystal structures of interleukin-2 tyrosine kinase and their implications for the design of selective inhibitors. J.Biol.Chem., 279:18727-18732, 2004 Cited by PubMed: 14766749 DOI: 10.1074/jbc.M400031200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation