1UWJ
The complex of mutant V599E B-RAF and BAY439006.
Summary for 1UWJ
Entry DOI | 10.2210/pdb1uwj/pdb |
Related | 1UWH |
Descriptor | B-RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE, 4-{4-[({[4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL]AMINO}CARBONYL)AMINO]PHENOXY}-N-METHYLPYRIDINE-2-CARBOXAMIDE (3 entities in total) |
Functional Keywords | transferase, threonine-protein kinase, signal transduction |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Nucleus : P15056 |
Total number of polymer chains | 2 |
Total formula weight | 63950.63 |
Authors | Barford, D.,Roe, S.M.,Wan, P.T.C.,Cancer Genome Project (deposition date: 2004-02-05, release date: 2004-03-19, Last modification date: 2024-05-01) |
Primary citation | Wan, P.T.C.,Garnett, M.J.,Roe, S.M.,Lee, S.,Niculescu-Duvaz, D.,Good, V.M.,Jones, C.M.,Marshall, C.J.,Springer, C.J.,Barford, D.,Marais, R. Mechanism of Activation of the Raf-Erk Signaling Pathway by Oncogenic Mutations of B-Raf Cell(Cambridge,Mass.), 116:855-, 2004 Cited by PubMed: 15035987DOI: 10.1016/S0092-8674(04)00215-6 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.5 Å) |
Structure validation
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