1UWJ
The complex of mutant V599E B-RAF and BAY439006.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | B-RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE | polymer | 276 | 31510.5 | 2 | UniProt (P15056) Pfam (PF07714) In PDB | HOMO SAPIENS (HUMAN) | BRAF, V-RAF MURINE SARCOMA VIRAL ONCOGENE HOMOLOG B1, P94 |
| 2 | A, B | 4-{4-[({[4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL]AMINO}CARBONYL)AMINO]PHENOXY}-N-METHYLPYRIDINE-2-CARBOXAMIDE | non-polymer | 464.8 | 2 | Chemie (BAX) | |||
| 3 | water | water | 18.0 | 1 | Chemie (HOH) |
Sequence modifications
A, B: 447 - 722 (UniProt: P15056)
| PDB | External Database | Details |
|---|---|---|
| Glu 599 | Val 599 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 63021.0 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 929.6 | |
| All* | Total formula weight | 63950.6 |
